当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Design of a pH-sensitive magnetic composite hydrogel based on salecan graft copolymer and Fe3O4@SiO2 nanoparticles as drug carrier.

Design of a pH-sensitive magnetic composite hydrogel based on salecan graft copolymer and Fe3O4@SiO2 nanoparticles as drug carrier.

Abstract：

:Salecan, a novel water-soluble extracellular β-glucan, is very suitable for the hydrogel preparation. Here, pH-sensitive magnetic composite hydrogel was fabricated by the graft copolymerization of crotonic acid (CA) and N-(hydroxymethyl) acrylamide (HMAA) onto salecan in the presence of Fe3O4@SiO2 nanoparticles for doxorubicin (DOX) delivery. The embedment of Fe3O4@SiO2 nanoparticles into salecan-g-poly(CA-co-HMAA) hydrogel network endowed the material with magnetic property. In addition, DOX not only achieved effectively bound to the composite hydrogel, but also released in a controlled and pH-dependent manner. The application of an external magnetic field could significantly enhance the drug release rate. More importantly, the released DOX preserved its bioavailability. Taken together, these hydrogel drug carriers provide a promising platform for magnetically targeted drug delivery.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Hu X,Wang Y,Zhang L,Xu M,Zhang J,Dong W

doi

10.1016/j.ijbiomac.2017.10.043

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

1811-1820

issue

Pt B

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)33244-0

journal_volume

107

pub_type

杂志文章

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