Indole-3-acetic acid/diol based pH-sensitive biological macromolecule for antibacterial, antifungal and antioxidant applications.

Abstract:

:Indole-3-acetic acid (IAA)/diol based pH-sensitive biopolymeric hydrogels with tunable biological properties (cytotoxicity, anti-oxidant and anti-fungal) have been synthesized via condensation polymerization. The present study focused on the synthesis of heterocyclic hydrogel using citric acid (CA), indole-3-acetic acid (IAA) and diethylene glycol (DEG) by condensation polymerization. The hydrogels revealed a pH-sensitive swelling behaviour, with increased swelling in acidic media, then turns to decreased the swelling in the basic media. The hydrogel samples were tested for antifungal activity against Aspergillus fumigates, Rhizopusoryzae and Candida albicans at different concentrations using ketoconazole as positive control and DMSO as negative control for antifungal activity. Antioxidant activity increasing nature in DPPH than NO radical compared with rutin and confirmed non toxic property using cytotoxicity analysis. The biopolymeric hydrogels were characterized by Fourier transform infrared (FT-IR) spectroscopy, 1H NMR,13C NMR, TGA, DSC followed by scanning electron microscopy (SEM). Such hydrogels with antioxidant properties is recommended for medical applications such as bandages, catheters, drains and tubes to prevent infection.

journal_name

Int J Biol Macromol

authors

G C,D S F,S S,M S,S G

doi

10.1016/j.ijbiomac.2016.11.068

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

363-375

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)31200-4

journal_volume

95

pub_type

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