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A systematic evaluation of hydroxyethyl starch as a potential nanocarrier for parenteral drug delivery.

Abstract：

:Development of parenteral nanoformulations is highly challenging due to the stringent demands on stability, reproducibility and high drug loading with minimal excipients. This study focuses on the development of a pharmaceutically acceptable nanomatrix system for parenteral delivery based on Hydroxyethyl Starch (HES), a FDA approved polymer that is relatively unexplored in drug delivery research. HES nanoparticles were prepared through a simple, two-step crosslinking-precipitation route, yielding 160±5 nm, nearly monodispersed spherical particles with high colloidal stability. The utility of this nanocarrier for parenteral delivery was verified by a panel of hemo/cytocompatibility assays at high concentrations (0.05-1 mg/ml) in vitro and in vivo. HES nanomatrix was found effective in encapsulating two chemically distinct drugs having varying hydrophobicities, with the release behavior being influenced by their chemical nature and drug-matrix interactions. Better in vitro efficacy was measured for the nanoencapsulated drug than its bare form, establishing the potential of HES nanocarriers for controlled drug delivery.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Narayanan D,Nair S,Menon D

doi

10.1016/j.ijbiomac.2014.12.012

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

575-84

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(14)00816-2

journal_volume

74

pub_type

杂志文章

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