当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice.

Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice.

Abstract：

:Dysbiosis of gut microbiota and low grade inflammation has gradually become a highly potential therapeutic agent for diabetic nephropathy (DN). It has been reported that a large number of polysaccharides have positive effects on DN, including Bupleurum polysaccharides. However, the mechanism remained unclear. This study selected two Bupleurum polysaccharides from different origins to investigate the potential relationship between kidney and gut. Diabetic mice model was established by streptozotocin (STZ, 100 mg/kg) and the treatment groups were treated with two Bupleurum polysaccharides (60 mg/kg) for 6 weeks, respectively. The results showed that the administration of Bupleurum polysaccharides ameliorated diabetic nephropathy induced by STZ. Blood glucose, blood creatinine and urine albumin were decreased after the oral administration of Bupleurum polysaccharides. And the dysbiosis of gut microbiota was modulated with higher diversity and gut protective microbiota. The gut barrier was also improved and the expression of inflammatory response both in kidney and colon was reduced. These results provided the evidence that modulating the gut microbiota and inflammation was involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice and laid the foundation for the deeper, specific mechanism research on the interaction between kidney and gut.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Feng Y,Weng H,Ling L,Zeng T,Zhang Y,Chen D,Li H

doi

10.1016/j.ijbiomac.2019.03.242

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

1001-1011

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)30302-2

journal_volume

132

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Understanding the adhesion mechanism of a mucin binding domain from Lactobacillus fermentum and its role in enteropathogen exclusion.

    abstract：:Lactobacillus species possesses surface exposed Mucin Binding Protein (MucBP) which plays a role in adhesion to gastrointestinal mucin. MucBP contains one or more mucin binding domain (MBD), the functionality of which has yet not been characterized thoroughly. Here, we have characterized a 93-amino acid MBD (MBD93) of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.107

    authors： Chatterjee M,Pushkaran AC,Vasudevan AK,Menon KKN,Biswas R,Mohan CG

    更新日期：2018-04-15 00:00:00

  • Extraction of polysaccharides from maca: Characterization and immunoregulatory effects on CD4+ T cells.

    abstract：:The immunomodulatory effects of maca polysaccharides (MCPs) on macrophages have been demonstrated in many studies. However, the effects of MCPs on CD4+ T cells have not been studied. Four water-soluble MCPs, labeled MCP1 (weight-average molecular weights [Mws] of 896.1 and 276.6 kDa), MCP2 (Mws of 337.8 and 219.0 kDa)...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.098

    authors： Chang Y,Lu W,Chu Y,Yan J,Wang S,Xu H,Ma H,Ma J

    更新日期：2020-07-01 00:00:00

  • Sequence-specific B-to-Z transition in self-assembled DNA: A biophysical and thermodynamic study.

    abstract：:The most remarkable conformational transition in nature is the B-to-Z transition of DNA which not only contributes for epigenetic regulation but also is exploited to create several advanced nanomaterials for sensing and nanomechanics. The present communication focuses on the intrinsic factors that control the La3+/Ce3...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.06.166

    authors： Bhanjadeo MM,Baral B,Subudhi U

    更新日期：2019-09-15 00:00:00

  • Soy protein isolate supplemented silk fibroin nanofibers for skin tissue regeneration: Fabrication and characterization.

    abstract：:Biocompatible soy protein isolate/silk fibroin (SPI/SF) nanofibrous scaffolds were successfully fabricated through electrospinning a novel protein blend SPI/SF. Prepared nanofibers were treated with ethanol vapor to obtain an improved water-stable structure. Fabricated scaffolds were characterized through scanning ele...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.090

    authors： Varshney N,Sahi AK,Poddar S,Mahto SK

    更新日期：2020-10-01 00:00:00

  • Bio-based poly (γ-glutamic acid) hydrogels reinforced with bacterial cellulose nanofibers exhibiting superior mechanical properties and cytocompatibility.

    abstract：:Natural polymer hydrogels are expected to be promising biomaterial because of its excellent biocompatibility and biodegradability, but they are soft and easily broken. Herein, the poly (γ-glutamic acid) (γ-PGA)/bacterial cellulose (BC) composite hydrogels with excellent mechanical properties were constructed by introd...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.12.148

    authors： Dou C,Li Z,Gong J,Li Q,Qiao C,Zhang J

    更新日期：2021-02-15 00:00:00

  • Preparation and characterization of TiO2-Ag loaded fish gelatin-chitosan antibacterial composite film for food packaging.

    abstract：:In this study, fish gelatin and chitosan were used as the film-forming substrate, and different concentrations of TiO2-Ag were added to prepare composite films. The physicochemical characteristics and microstructure of the films were studied. The results showed that the addition of TiO2-Ag significantly increased the ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.070

    authors： Lin D,Yang Y,Wang J,Yan W,Wu Z,Chen H,Zhang Q,Wu D,Qin W,Tu Z

    更新日期：2020-07-01 00:00:00

  • A novel glycosaminoglycan-like polysaccharide from abalone Haliotis discus hannai Ino: purification, structure identification and anticoagulant activity.

    abstract：:A novel glycosaminoglycan-like sulfated polysaccharide (AAP) from the pleopods of Haliotis discus hannai Ino was purified by DEAE ion exchange chromatography followed with S-300 HR geltrion chromatography. Chemical composition analysis indicated that AAP was composed of galactosamine, glucuronic acid, fucose, galactos...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.09.017

    authors： Li G,Chen S,Wang Y,Xue Y,Chang Y,Li Z,Wang J,Xue C

    更新日期：2011-12-01 00:00:00

  • Alginate-based hydrogels for cancer therapy and research.

    abstract：:Cancer is a major health issue concerning to all of us. Current treatment options are still limited due to not-selective action. Encapsulation is contemplated as an innovative approach to address systemic toxicity and tumor resistance caused by traditional therapies, while increasing encapsulated compounds bioavailabi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.12.161

    authors： Reig-Vano B,Tylkowski B,Montané X,Giamberini M

    更新日期：2021-02-15 00:00:00

  • Synthesis of chitosan derivative graft acrylic acid superabsorbent polymers and its application as water retaining agent.

    abstract：:A new superabsorbent polymer was synthesized using amino ethyl chitosan and an acrylic acid by a free radical polymerization. The chemical structure of the superabsorbent polymer was characterized using FTIR, TGA, XRD and solid-state 13C NMR. The results revealed that the acrylic acid was successfully grafted onto the...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.04.072

    authors： Fang S,Wang G,Li P,Xing R,Liu S,Qin Y,Yu H,Chen X,Li K

    更新日期：2018-08-01 00:00:00

  • Antioxidant and anti-aging activities of polysaccharides from Cordyceps cicadae.

    abstract：:Cordyceps cicadae is a traditional Chinese medicine with high nutritional value and biological activities. Previously, we reported on the antioxidant activity associated with the polysaccharides from Cordyceps cicadae (CP). To further explore which of the fraction of CP had the greatest potency, in here, the in vitro ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.163

    authors： Zhu Y,Yu X,Ge Q,Li J,Wang D,Wei Y,Ouyang Z

    更新日期：2020-08-15 00:00:00

  • Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles.

    abstract：:Tamoxifen (Tmx) embedded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA-Tmx) is prepared to evaluate its better DNA cleavage potential, cytotoxicity using Dalton's lymphoma ascite (DLA) cells and MDA-MB231 breast cancer cells. PLGA-Tmx nanoparticles are prepared through emulsified nanoprecipitation technique...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.04.065

    authors： Pandey SK,Patel DK,Maurya AK,Thakur R,Mishra DP,Vinayak M,Haldar C,Maiti P

    更新日期：2016-08-01 00:00:00

  • Amorphous aggregate adducts of linker histone H1 turn highly immunologic in the cancers of oesophagus, stomach, gall bladder and ovary.

    abstract：:Hyperglycaemic influence on carcinogenesis and tumour progression is emerging as a link between diabetes and cancer. This work establishes the disturbed structural integrity of nucleosomal linker histone H1 by methyglyoxal (MG) and then correlates the role of modified H1 in the auto-immunopathogenesis of multiple canc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.12.060

    authors： Mir AR,Moinuddin,Habib S

    更新日期：2017-03-01 00:00:00

  • Self-assembling crystals of an extract of Flos Sophorae Immaturus for improving the antioxidant, mechanical and barrier properties of a cassia gum film.

    abstract：:A novel antioxidative film was prepared by drying a film-forming solution containing the Flos Sophorae Immaturus extract (FSIE) (0-3.5%) and cassia gum (CG). Scanning electron microscopy (SEM) showed that FSIE was successfully compounded with CG. Although the addition of FSIE slightly increased the water vapor permeab...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.082

    authors： Meng F,Zhang C,Li J,Wang L

    更新日期：2021-01-15 00:00:00

  • Preparation and properties of cellulose nanocomposite films with in situ generated copper nanoparticles using Terminalia catappa leaf extract.

    abstract：:In the present work, copper nanoparticles (CuNPs) were in situ generated inside cellulose matrix using Terminalia catappa leaf extract as a reducing agent. During this process, some CuNPs were also formed outside the matrix. The CuNPs formed outside the matrix were observed with transmission electron microscope (TEM) ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.09.114

    authors： Muthulakshmi L,Rajini N,Nellaiah H,Kathiresan T,Jawaid M,Rajulu AV

    更新日期：2017-02-01 00:00:00

  • Size effect-inspired fabrication of konjac glucomannan/polycaprolactone fiber films for antibacterial food packaging.

    abstract：:The exploration of new methods to produce food packaging with excellent physicochemical and antibacterial properties is of great scientific and technological interest. Here, we successfully prepare the food packaging films that are composed of konjac glucomannan (KGM), poly(ε-caprolactone) (PCL) and silver nanoparticl...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.242

    authors： Lin W,Ni Y,Pang J

    更新日期：2020-04-15 00:00:00

  • Chitosan and gelatin materials incorporated with phenolic extracts of grape seed and jabuticaba peel: Rheological, physicochemical, antioxidant, antimicrobial and barrier properties.

    abstract：:In this study, chitosan and gelatin materials incorporated with grape seed (Vitis vinifera L.) (VSE) and jabuticaba peel (Plinia cauliflora) (PPE) extracts were developed with potential application as food coatings. It was evaluated how the concentration of the extracts and their addition order in the polymeric matrix...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.240

    authors： Rodrigues MÁV,Bertolo MRV,Marangon CA,Martins VDCA,Plepis AMG

    更新日期：2020-10-01 00:00:00

  • Purification and characterization of thermostable superoxide dismutase from Anoxybacillus gonensis KA 55 MTCC 12684.

    abstract：:A thermostable superoxide dismutase from thermophilic bacterium Anoxybacillus gonensis KA 55 MTCC 12684 which was isolated from Manikaran hotspring of Himachal Pradesh was purified to apparent homogeneity by fractional ammonium sulphate precipitation and anion exchange chromatography. A purification factor of 33.1-fol...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.06.031

    authors： Bhatia K,Mal G,Bhar R,Jyoti,Attri C,Seth A

    更新日期：2018-10-01 00:00:00

  • Unexpected effect of magnetic nanoparticles on the performance of aqueous removal of toxic Cr(VI) using modified biopolymer chitosan.

    abstract：:Modified biopolymer chitosan namely 2-hydroxy-1-naphthaldehyde chitosan (CTS-Nap) has been synthesized for the removal of toxic chromium from aqueous solutions. In an attempt to enhance the adsorption capacity of toxic chromium on the prepared modified biopolymer, magnetic Fe3O4 nanoparticles have been loaded on the m...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.12.188

    authors： Khalil TE,Elhusseiny AF,Ibrahim NM,El-Dissouky A

    更新日期：2021-02-15 00:00:00

  • Selection and mutational analyses of the substrate interacting residues of a chitinase from Enterobacter cloacae subsp. cloacae (EcChi2) to improve transglycosylation.

    abstract：:Transglycosylation (TG) by Enterobacter cloacae subsp. cloacae chitinase 2 (EcChi2) has been deciphered by site-directed mutagenesis. EcChi2 originally displayed feeble TG with chitin oligomer with a degree of polymerization (DP4), for a short duration. Based on the 3D modelling and molecular docking analyses, we alte...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.10.125

    authors： Mallakuntla MK,Vaikuntapu PR,Bhuvanachandra B,Podile AR

    更新日期：2020-12-15 00:00:00

  • TRIP13 is a predictor for poor prognosis and regulates cell proliferation, migration and invasion in prostate cancer.

    abstract：:Thyroid hormone receptor interactor 13 (TRIP13) has been reported to be overexpressed in serval types of human cancers, and regulate tumor cell proliferation, migration and invasion. However, the role of TRIP13 in prostate cancer was still unclear. In our study, the correlation between TRIP13 expression and clinical p...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.168

    authors： Dong L,Ding H,Li Y,Xue D,Li Z,Liu Y,Zhang T,Zhou J,Wang P

    更新日期：2019-01-01 00:00:00

  • Structural investigation on damaged hair keratin treated with α,β-unsaturated Michael acceptors used as repairing agents.

    abstract：:Many restoring formulations for damaged hair keratin have been developed. Some patents claim that the hair repair occurs through the reconstruction of disulfide bridges of keratin, through α,β-unsaturated Michael acceptors, such as shikimic acid and bis-aminopropyl diglycol dimaleate. To gain more insights into the po...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.194

    authors： Di Foggia M,Boga C,Micheletti G,Nocentini B,Taddei P

    更新日期：2021-01-15 00:00:00

  • Effects of temperature and solvent condition on phase separation induced molecular fractionation of gum arabic/hyaluronan aqueous mixtures.

    abstract：:Effects of temperature and solvent condition on phase separation-induced molecular fractionation of gum arabic/hyaluronan (GA/HA) mixed solutions were investigated. Two gum arabic samples (EM10 and STD) with different molecular weights and polydispersity indices were used. Phase diagrams, including cloud and binodal c...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.073

    authors： Hu B,Han L,Gao Z,Zhang K,Al-Assaf S,Nishinari K,Phillips GO,Yang J,Fang Y

    更新日期：2018-09-01 00:00:00

  • Evaluation of polyurethane based on cellulose derivative-ketoprofen biosystem for implant biomedical devices.

    abstract：:A polyether-urethane based on polytetrahydrofuran containing hydroxypropyl cellulose for biomedical applications was tested for its biocompatibility. Ketoprofen was incorporated (3% and 6%) in the polyurethane matrix as an anti-inflammatory drug. Dynamic vapour sorption method was employed for testing the water sorpti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.09.026

    authors： Macocinschi D,Filip D,Vlad S,Butnaru M,Knieling L

    更新日期：2013-01-01 00:00:00

  • Poly-acrylic acid grafted natural rubber for multi-coated slow release compound fertilizer: Preparation, properties and slow-release characteristics.

    abstract：:In this study, a novel multi-coated slow release compound fertilizer based on natural rubber (NR) was prepared and characterized. Firstly, NR was grafted with poly-acrylic acid by in-situ radical solution polymerization to synthesize poly-acrylic acid grafted natural rubber (NR-g-PAA), the reaction conditions were opt...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.051

    authors： Cui Y,Xiang Y,Xu Y,Wei J,Zhang Z,Li L,Li J

    更新日期：2020-03-01 00:00:00

  • Mechanical, structural and physical aspects of chitosan-based films as antimicrobial dressings.

    abstract：:Chitosan is a biodegradable, non-toxic, and antimicrobial polymer. Chitosan films can be used as a dressing because they promote the healing of cutaneous ulcers. In this study, the mechanical, physical, and microbiological properties films of pure chitosan and films formulated with a glycerol-honey mixture were charac...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.04.149

    authors： Escárcega-Galaz AA,Sánchez-Machado DI,López-Cervantes J,Sanches-Silva A,Madera-Santana TJ,Paseiro-Losada P

    更新日期：2018-09-01 00:00:00

  • Biochemical and functional characterization of an atypical plant l-arginase from Cilantro (Coriandrum sativam L.).

    abstract：:Arginase is one of the key enzymes responsible for maintaining the essential levels of nitrogen among plants, but biochemical and functional characterization of arginase among plants is limited. While screening for stable plant arginase, we found cilantro possessing an abundant and stable arginase. We purified arginas...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.06.096

    authors： Siddappa S,Basrur V,Ravishankar Rai V,Marathe GK

    更新日期：2018-10-15 00:00:00

  • Developing a simultaneously antioxidant and pH-responsive κ-carrageenan/hydroxypropyl methylcellulose film blended with Prunus maackii extract.

    abstract：:к-Carrageenan and hydroxypropyl methylcellulose were used as matrix materials in which the extract of Prunus maackii pomace (EPm) was added to prepare a simultaneously antioxidant and pH-responsive film. EPm effectively increased the flexibility, barrier properties, antioxidant activity and pH-responsiveness of the fi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.114

    authors： Sun G,Chi W,Xu S,Wang L

    更新日期：2020-07-15 00:00:00

  • Iron oxides decorated graphene oxide/chitosan composite beads for enhanced Cr(VI) removal from aqueous solution.

    abstract：:This study is the first to evaluate the effects of Iron oxides (FeOx) species and their decoration on graphene oxide/chitosan (GO/CS) composites for Cr(VI) removal and the possibility of Fe secondary pollution. Results show that Fe(III) is a better decoration material than Fe(II) and decoration through immersion-evapo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2021.01.060

    authors： Shan H,Zeng C,Zhao C,Zhan H

    更新日期：2021-01-13 00:00:00

  • Inhibition of methemoglobin formation in aqueous solutions under aerobic conditions by the addition of amino acids.

    abstract：:Hemoglobin (Hb) as an important iron-containing oxygen-transport protein is easily oxidized to the ferric met-form, methemoglobin (metHb), and loses the capacity of binding oxygen during storage. In this study, the experimental data indicate that the presence of Tyr and Glu significantly suppress the metHb formation i...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.12.010

    authors： Wei Y,Li C,Zhang L,Su Z,Xu X

    更新日期：2014-03-01 00:00:00

  • Active edible films of methylcellulose with extracts of green apple (Granny Smith) skin.

    abstract：:The aim a present study was developed methylcellulose (MC) active edible films with extracts of green apple skin, as model systems of edible coating. Active edible films were developed by incorporation of ethanolic extract of freeze-dried apple skin (EEFD) and aqueous extract of apple skin (AES) at 10, 20 and 25% (v/v...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.12.114

    authors： Matta E,Tavera-Quiroz MJ,Bertola N

    更新日期：2019-03-01 00:00:00