Macromolecular agents with antimicrobial potentialities: A drive to combat antimicrobial resistance.

Abstract:

:In recent years, the antimicrobial resistance (AMR) or multidrug resistance (MDR) has become a serious health concern and major challenging issue, worldwide. After decades of negligence, the AMR has now captured global attention. The increasing number of antibiotic-resistant strains has threatened the achievements of science and medicine since it inactivates conventional antimicrobial therapeutics. Scientists are trying to respond to AMR/MDR threat by exploring innovative platforms and new therapeutic strategies to tackle infections from these resistant strains and bypass treatment limitations related to these pathologies. The present review focuses on the utilization of bio-inspired novel constructs and their potential applications as novel antimicrobial agents. The first part of the review describes plant-based biological macromolecules containing an immense variety of secondary metabolites, which could be potentially used as alternative strategies to combat antimicrobial resistance. The second part discusses the potential of metal-based macromolecules as effective antimicrobial platforms for preventing infections from resistant strains. The third part comprehensively elucidates how nanoparticles, in particular, metal-integrated nanoparticles can overcome this AMR or MDR issue. Towards the end, information is given with critical concluding remarks, gaps, and finally envisioned with future considerations.

journal_name

Int J Biol Macromol

authors

Bilal M,Rasheed T,Iqbal HMN,Hu H,Wang W,Zhang X

doi

10.1016/j.ijbiomac.2017.05.071

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

554-574

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)30763-8

journal_volume

103

pub_type

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