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A simple MWCNTs@paper biosensor for CA19-9 detection and its long-term preservation by vacuum freeze drying.

Abstract：

:This paper introduces a cheap simple MWCNTs@paper biosensor for the detection of CA19-9, which is a biomarker of pancreatic cancer. By adding the CA19-9 antibody to the surface of MWCNTs which are deposited on the microporous filter paper, the correlation between the concentration of CA19-9 and resistance of biosensor element was linear due to the site-specific binding of antigen and antibody. The detection range is wide (0 U/mL-at least 1000 U/mL), and even in the low concentration of CA19-9, the linearity remains satisfying. Based on this property, it could be used for the detection of early-stage pancreatic cancer. Besides, this research originally introduces a vacuum freeze-drying method for the long-term preservation of biosensor, prolonging its storage time from 3 h to at least 7 days, which signifcantly promoted its value in practical application. One piece of the MWCNTs@paper biosensor only cost $2 (about 30 times cheaper than ELISA) approximately, and the detection speed is satisfying (2 h, 12 times faster than ELISA), which will possibly increase its opportunity of mass production and clinical practice.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Jin W,Zhang R,Dong C,Jiang T,Tian Y,Yang Q,Yi W,Hou J

doi

10.1016/j.ijbiomac.2019.09.176

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

995-1003

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)34112-1

journal_volume

144

pub_type

杂志文章

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