当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Anti-tumor activity and the mechanism of a green tea (Camellia sinensis) polysaccharide on prostate cancer.

Anti-tumor activity and the mechanism of a green tea (Camellia sinensis) polysaccharide on prostate cancer.

Abstract：

:In this study, a homogeneous polysaccharide (GTP), with a molecular weight of 7.0 × 104 Da, was isolated from Green tea, which was only composed of glucose. The antitumor effects of GTP on prostate cancer (PC) cell line along with the possible mechanism was examined. First, we investigate the potential role of microRNA-93 (miR-93) in PC progression. Our results showed that miR-93 was significantly upregulated in human PC tissues and several PC cell lines, and its overexpression was correlated with poor survival in PC patients. Furthermore, functional analysis showed that miR-93 overexpression promoted the migration, invasion and proliferation of PC-3 cells transfected with miR-93 mimics, while its knockdown displayed an opposite result in DU145 cells following miR-93 inhibitor transfection. Additionally, in vivo tumorigenic studies on nude mice confirmed that miR-93 mimic treatment accelerated the growth of PC-3 xenograft tumors. As expected, GTP (25, 50 and 100 μg/ml) inhibited growth of PC-3 cells via inducing apoptosis, which was achieved by elevation of bax/bcl-2 ratio and caspae-3 protein expression, as well as a decrease of miR-93. Thus, miR-93 may be a potential therapeutic target by GTP for PC therapy.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Yang K,Gao ZY,Li TQ,Song W,Xiao W,Zheng J,Chen H,Chen GH,Zou HY

doi

10.1016/j.ijbiomac.2018.10.101

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

95-103

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)33359-2

journal_volume

122

pub_type

杂志文章

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