Zn2+-loaded TOBC nanofiber-reinforced biomimetic calcium alginate hydrogel for antibacterial wound dressing.

Abstract:

:Calcium alginate hydrogel dressing is an excellent hydrogel dressing because of its excellent absorption characteristics and tear-free pain. However, its application is limited by its poor mechanical properties and non-bacterial properties. Here, we reported a new biomimetic hydrogel dressing with good mechanical properties and antibacterial properties by 2,2,6,6-tetramethylpiperidine-1-oxyl oxidized bacterial cellulose (TOBC) intensified and a simple method for loading Zn2+. The results indicated that the mechanical properties were obviously improved by adding 20 wt% TOBC due to the formation of conjoined-network structure. When the concentration of Zn2+ is controlled at about 0.0001 wt%, the hydrogel has good antimicrobial and biological properties. This study provides a simple and sufficient method to prepare new biomimetic antimicrobial hydrogel dressings with good properties.

journal_name

Int J Biol Macromol

authors

Zhang M,Chen S,Zhong L,Wang B,Wang H,Hong F

doi

10.1016/j.ijbiomac.2019.12.046

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

235-242

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)39067-1

journal_volume

143

pub_type

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