Abstract：
:An effective method of free radical degradation induced by H2O2/ascorbic acid, which was different from previously reported H2O2/Cu2+ method, was developed to depolymerize a novel glycosaminoglycan from Holothuria mexicana (HmG). The results indicated that the degradation efficiency increased with the reduced solution concentration, increased H2O2 concentration and ascorbic acid concentration. The chemical composition and structure of different molecular HmG were analyzed. The results showed that the primary structure and sulfate esters were well reserved during the degradation. Two dimension nuclear magnetic resonance of a low molecular product (DHmG-2) indicate that it contained chondroitin sulfate backbone and major 4-O-sulfated fucose branches. The antioxidant assays of HmG and DHmG-3 showed a fine scavenging abilities on 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide and hydroxyl radicals in concentration dependent manner. Besides, molecular weight did not obviously affect the antioxidant activities of HmG.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Mou J,Wang C,Li Q,Qi X,Yang Jdoi
10.1016/j.ijbiomac.2017.10.161subject
Has Abstractpub_date
2018-02-01 00:00:00pages
1339-1347issue
Pt Aeissn
0141-8130issn
1879-0003pii
S0141-8130(17)33214-2journal_volume
107pub_type
杂志文章abstract：:The purpose of this study was to compare the application of several extraction methods, including cold extraction (CAE), hot extraction (HAE), ultrasonic-assisted extraction (UAE), and microwave-assisted extraction (MAE), all carried out in 0.1 M NaOH, under their respective best parameters, for obtaining products fro...
journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2015.11.003
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:Long non-coding RNAs are emerging as key molecules in cancer progression. LncRNA-CCAL has shown to be highly expressed and important in regulating CRC and osteosarcoma development. Nevertheless, the expression and mechanism of CCAL in HCC is still not well understood. METHODS:qRT-PCR and ISH were used to eva...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2017.12.110
更新日期：2018-04-01 00:00:00
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2010.11.006
更新日期：2011-01-01 00:00:00
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2019.04.058
更新日期：2019-07-15 00:00:00
