Abstract：
:Chitosan and heparin were covalently immobilized onto a poly(lactic acid-co-glycolic acid) (PLGA) surface using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (EDC), N-hydroxysuccinimide (NHS) in a 2-morpholinoethane sulfonic acid (MES) buffer system. The properties of the modified PLGA surface and the control were investigated by water contact angle measurement and electron spectroscopy for chemical analysis (ESCA). The water contact angle of the modified film was greatly decreased and the element content on the surface of the films changed correspondingly. Platelet adhesion assay showed that blood compatibility of the chitosan/heparin modified film was improved while hepatocyte culture indicated that the cell compatibility of the modified film was enhanced.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Wang XH,Li DP,Wang WJ,Feng QL,Cui FZ,Xu YX,Song XHdoi
10.1016/s0141-8130(03)00072-2keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
95-100issue
1-3eissn
0141-8130issn
1879-0003pii
S0141813003000722journal_volume
33pub_type
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