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Synthesis of a novel biocompatible nanocomposite of graphene oxide and magnetic nanoparticles for drug delivery.

Abstract：

:The combination of imaging and delivery systems through nanoscale material have been used to create new nanoparticle formulations for biological applications. Here, a magnetic nanocomposite consisting of superparamagnetic iron oxide nanoparticles (SPIONs), graphene oxide (GO), chitosan and poly(vinyl alcohol) (PVA) as biocompatible polymers was synthesized for applying in drug delivery and imaging agent. The nanocomposite was studied by various techniques including XRD, TEM, FE-SEM, FT-IR and VSM. SPIONs had an average diameter size about 10nm and showed superparamagnetic behavior. Also, TEM and SEM images showed that these nanoparticles successfully attached on the surface of GO sheets. Finally, 5-fu was loaded onto these nanocomposite particles in order to study of entrapment efficiency and drug release behavior of nanocomposite particles. They showed high drug entrapment efficiency and more and faster drug release in acidic pH.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Aliabadi M,Shagholani H,Yunessnia Lehi A

doi

10.1016/j.ijbiomac.2017.02.012

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

287-291

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)32731-3

journal_volume

98

pub_type

杂志文章

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