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A starch-based stimuli-responsive magnetite nanohydrogel as de novo drug delivery system.

Abstract：

:A novel starch-based stimuli-responsive magnetite nanohydrogel (MNHG), namely Fe3O4-g-[poly(N-isopropylacrylamide-co-maleic anhydride)]@strach; Fe3O4-g-(PNIPAAm-co-PMA)@starch, was successfully developed for targeted delivery of doxorubicin (DOX) as an anticancer drug. First, magnetite nanoparticles (MNPs) was modified using chloroacetyl chloride moiety followed by grafting of NIPAAm and MA monomers through ATRP technique. The resultant Fe3O4-g-(PNIPAAm-co-PMA) nanocomposite was crosslinked through the reaction between the anhydride group of MA and hydroxyl groups of starch to afford a Fe3O4-g-(PNIPAAm-co-PMA)@starch MNHG. The chemical structure of the synthesized materials were confirmed using Fourier transform infrared (FTIR) spectroscopy. Furthermore, morphology, size, thermal property, and magnetic properties of the synthesized MNHG were studied. This MNHG was loaded with DOX, and drug loading and encapsulation efficiencies as well as pH- and temperature-responsive drug release behavior of the fabricated MNHG were also evaluated. As results, we envision that the developed MNHG has potential as de novo drug delivery system (DDS) due to its smart physicochemical features.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Massoumi B,Mozaffari Z,Jaymand M

doi

10.1016/j.ijbiomac.2018.05.211

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

418-426

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)30621-4

journal_volume

117

pub_type

杂志文章

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