Abstract:
:A water-soluble polysaccharide (EPA-1) from Pleurotus eryngii was obtained using DEAE-52 and Sephadex G-50 columns. The properties, structure and immunomodulatory activity of EPA-1 were studied. The results demonstrated that EPA-1 was a homogeneous polysaccharide with the molecular weight of 9.97×104Da. EPA-1 consisted of Man, Glc and Gal in a molar ratio of 2.2:1.0:3.2. The characterized fragment structures of EPA-1 were found to be consisting of seven sugar residues and two branches by GC-MS, FTIR and NMR analyses. Among them, the (1→6)-linkedGal residue was the main linkage mode of EpA-1 and composed of its backbone. Activity tests indicated that EPA-1 significantly induced macrophage to release the immune activity factor of NO, TNF-α, IL-1 and IL-6 through activation of signal protein of p38, ERK, JNK in MAPKs and translocation of nuclear NF-κΒ, indicating EPA-1 to possess good immunoregulatory activity.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Xu D,Wang H,Zheng W,Gao Y,Wang M,Zhang Y,Gao Qdoi
10.1016/j.ijbiomac.2016.07.016subject
Has Abstractpub_date
2016-11-01 00:00:00pages
30-36eissn
0141-8130issn
1879-0003pii
S0141-8130(16)30739-5journal_volume
92pub_type
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