Abstract:
:Cu(II) 12-MCCu(II)PyrAcHA-4 metallacrown was studied by several spectroscopic techniques as an interacting ligand with G-quadruplex DNA structures. Investigations were performed on oligonucleotides bearing human telomeric and protooncogenic c-myc sequences in buffered solution mimicking ionic conditions in cellular environment. The planar square-based Cu(II) 12-MC-4 metallacrown interacts with GQ via an end-stacking mode with 1:1 stoichiometry. Circular dichroism (CD) titration revealed capability of this metallacrown to induce transformation of the GQ hybrid topology into the parallel form. Thermal melting experiment indicated higher thermal stability of both antiparallel (ΔTm = +15 °C) and parallel (ΔTm = ≥27 °C) G-quadruplexes in the presence of Cu (II) 12-MC-4. Indirect GQ FID assay let to determine high binding affinity of the Cu(II) 12-MC-4 to antiparallel 22Htel/Na+ GQ (KMC = 3.9 (±0.4) x 106 M-1). Comparing with lower binding constants previously reported for Ln (III) 15-MC-5 and Sm (III) 12-MC-4, one can conclude that the square planar geometry and the positive charge of metallacrown play an important role in MC/GQ interactions.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Rajczak E,Juskowiak Bdoi
10.1016/j.ijbiomac.2019.11.163subject
Has Abstractpub_date
2020-08-01 00:00:00pages
1258-1269eissn
0141-8130issn
1879-0003pii
S0141-8130(19)37555-5journal_volume
156pub_type
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