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Particles of liquid-crystalline dispersions formed by (nucleic acid-rare earth element) complexes as a potential platform for neutron capture therapy.

Abstract：

:Microscopic size particles of the cholesteric double-stranded DNA (RNA) liquid-crystalline dispersions, containing the ions of the rare earth elements in their content, have been obtained for the first time. The properties of these particles differ from those of classical DNA cholesterics noticeably. The local concentration of the rare earth elements in a particle reaches 200 mg/ml. The particles of the liquid-crystalline dispersion of the (DNA-gadolinium) complex maintain the properties for a long time. The combination of the microscopic size of particles, high concentration of gadolinium in particles and their stability opens a way to practical application of this new biomaterial.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Yevdokimov YM,Salyanov VI,Kondrashina OV,Borshevsky VI,Semenov SV,Gasanov AA,Reshetov IV,Kuznetsov VD,Nikiforov VN,Akulinichev SV,Mordovskoi MV,Potashev SI,Skorkin VM

doi

10.1016/j.ijbiomac.2005.10.001

keywords:

subject

Has Abstract

pub_date

2005-12-15 00:00:00

pages

165-73

issue

4

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(05)00207-2

journal_volume

37

pub_type

杂志文章

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