当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Protein-reduced gold nanoparticles mixed with gentamicin sulfate and loaded into konjac/gelatin sponge heal wounds and kill drug-resistant bacteria.

Protein-reduced gold nanoparticles mixed with gentamicin sulfate and loaded into konjac/gelatin sponge heal wounds and kill drug-resistant bacteria.

Abstract：

:Timely antibacterial treatment of wounds reduces the probability of wound infection and promotes wound healing. However, the materials used to treat wounds often fail to provide both sterilization (especially for super bacteria) and moisture, and some may even cause secondary injury to the wound. In this study, gold nanoparticles (Au NPs) of average grain diameter of 3 ± 1 nm were prepared using egg white as the reductant. These particles showed no aggregation and pink fluorescence. Au NPs were mixed with gentamicin sulfate (GS) and loaded into a mixture of konjac glucomannan (KGM) and gelatin as wound dressing (KGM/Gelatin@Au NPs/GS). Antibacterial experiments showed that the Au NPs amplified the antibacterial activity of GS; Au NPs/GS efficiently eliminated bacteria, especially super bacteria. Cytotoxicity tests indicated that KGM/Gelatin@Au NPs/GS showed basically no cytotoxicity to L929 cells. In addition, KGM/Gelatin@Au NPs/GS possesses good water absorption, water retention, and enhanced mechanical properties, which can provide a moist environment for wounds and promote healing. In conclusion, our study showed that the antibacterial activity of KGM/Gelatin@Au NPs/GS is better than that of only GS and that it efficiently eliminated super bacteria. Therefore, KGM/Gelatin@Au NPs/GS can be used for killing superbugs, inhibiting bacterial growth, and promoting wound healing.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zou Y,Xie R,Hu E,Qian P,Lu B,Lan G,Lu F

doi

10.1016/j.ijbiomac.2020.01.190

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

921-931

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)34916-5

journal_volume

148

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Development and in vitro characterization of chitosan/starch/halloysite nanotubes ternary nanocomposite films.

    abstract：:In this present study, ternary nanocomposite films of chitosan/starch/halloysite nanotubes (ChSHT) were fabricated by solution casting process. The ternary nanocomposite films were characterized by using various techniques such as Fourier transform infrared (FTIR), X-ray Diffraction (XRD), water contact angle, water a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.01.047

    authors： Devi N,Dutta J

    更新日期：2019-04-15 00:00:00

  • Multiparticulate based thermosensitive intra-pocket forming implants for better treatment of bacterial infections in periodontitis.

    abstract：:Considering alarming projections in the prevalence of periodontitis, following study was undertaken to develop chitosan-vanillin crosslinked microspheres loaded in-situ gel (MLIG) implants containing ornidazole and doxycycline hyclate for the treatment of pocket infections. Firstly, microspheres were formulated and op...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.04.179

    authors： Yadav SK,Khan G,Bansal M,Thokala S,Bonde GV,Upadhyay M,Mishra B

    更新日期：2018-09-01 00:00:00

  • Low molecular weight chitosan nanoparticles for CpG oligodeoxynucleotides delivery: Impact of molecular weight, degree of deacetylation, and mannosylation on intracellular uptake and cytokine induction.

    abstract：:Although synthetic CpG oligodeoxynucleotides (ODNs) have shown substantial potential as immunotherapeutic agents, their effective intracellular delivery remains challenging. In this work, nanoparticles prepared from low-molecular weight (LMW) chitosans were investigated as CpG ODN delivery systems. Chitosan samples wi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.048

    authors： Babii O,Wang Z,Liu G,Martinez EC,van Drunen Littel-van den Hurk S,Chen L

    更新日期：2020-09-15 00:00:00

  • Characterization of a novel bifunctional mannuronan C-5 epimerase and alginate lyase from Pseudomonas mendocina. sp. DICP-70.

    abstract：:Alginate is a family of industrially important linear polymers consisting of β-D-mannuronic acid (M) and its C-5 epimer α-L-guluronic acid (G). The function of alginate is closely related to the ratio of M/G. Mannuronan C-5 epimerase, which converts M to G, is a key enzyme involved in the biosynthesis of alginate. A n...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.126

    authors： Sun M,Sun C,Li T,Li K,Yan S,Yin H

    更新日期：2020-05-01 00:00:00

  • Fabrication of pure chitosan nanofibrous membranes as effective absorbent for dye removal.

    abstract：:The pure chitosan nanofibrous membranes with average fiber diameter of 86±18, 114±17,164±28nm were successfully prepared by electrospinning. Batch adsorption experiments of using chitosan nanofibrous membranes as adsorbent to remove acid blue-113 were conducted. The adsorption capacity of 1377mg/g was achieved by the ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.08.072

    authors： Li C,Lou T,Yan X,Long YZ,Cui G,Wang X

    更新日期：2018-01-01 00:00:00

  • A cyclic disulfide peptide reproduces in solution the main structural features of a native antigenic site of foot-and-mouth disease virus.

    abstract：:A cyclic disulfide peptide corresponding to the G-H loop sequence 134-155 [replacement Tyr136 and Arg153 with Cys] of the capsid protein VP1 of foot-and-mouth disease virus (FMDV) isolate C-S8c1 was examined by proton 2D-NMR spectroscopy in water and in 25% HFIP/water. In water, NMR data supported the presence of a no...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(97)01163-x

    authors： Haack T,Camarero JA,Roig X,Mateu MG,Domingo E,Andreu D,Giralt E

    更新日期：1997-06-01 00:00:00

  • Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative.

    abstract：:It has been established that the equilibrium between duplex and G-quadruplex of the nuclease hypersensitivity element III1 (NHE III1) in human c-myc promoter is linked with this gene's transcription. Using NMR and ESI-MS, we have found a pyrene derivative, DMAPP, is able to modulate this equilibrium and, thus, might h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.05.024

    authors： Zhang Z,He X,Yuan G

    更新日期：2011-12-01 00:00:00

  • Electrospun chitosan-graft-poly (ε -caprolactone)/poly (ε-caprolactone) cationic nanofibrous mats as potential scaffolds for skin tissue engineering.

    abstract：:This research is aimed to develop cationic nanofibrous mats with improved cellular adhesion profiles and stability of three-dimensional fibrous structure as potential scaffolds for skin tissue engineering. Firstly, amino-remained chitosan-graft-poly (ɛ-caprolactone) (CS-g-PCL) was synthesized with a facile one-step ma...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.09.019

    authors： Chen H,Huang J,Yu J,Liu S,Gu P

    更新日期：2011-01-01 00:00:00

  • Kinetics for Cu(2+) induced Sepia pharaonis arginine kinase inactivation and aggregation.

    abstract：:Arginine kinase plays an important role in cellular energy metabolism and is closely related to the environmental stress response in marine invertebrates. We studied the Cu(2+)-mediated inhibition and aggregation of Sepia pharaonis arginine kinase (SPAK) and found that Cu(2+) markedly inhibited the SPAK activity along...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.06.049

    authors： Shi XY,Zhang LL,Wu F,Fu YY,Yin SJ,Si YX,Park YD

    更新日期：2016-10-01 00:00:00

  • Exopolysaccharides production by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12: Optimization of fermentation variables and characterization of structure and bioactivities.

    abstract：:In this study, the most important variables (incubation temperature, fermentation time and yeast extract concentration) responsible for the exopolysaccharides (EPSs) production by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12 were screened. The EPSs synthesize by LA5, BB12, and their co...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.084

    authors： Amiri S,Rezaei Mokarram R,Sowti Khiabani M,Rezazadeh Bari M,Alizadeh Khaledabad M

    更新日期：2019-02-15 00:00:00

  • Structural modification and functional improvement of starch nanoparticles using vacuum cold plasma.

    abstract：:Starch nanoparticles (SNPs) have become one of the most interesting nanocarriers due to their relatively easy synthesis, biocompatibility, and biodegradability. However, the practical applications of SNPs are limited, as their aggregation reduce their functionality. Here, SNPs obtained by recrystallizing debranched wa...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.167

    authors： Chang R,Lu H,Tian Y,Li H,Wang J,Jin Z

    更新日期：2020-02-15 00:00:00

  • Gene expression studies and molecular characterization of a cathepsin L-like from the Asian citrus psyllid Diaphorina citri, vector of Huanglongbing.

    abstract：:Huanglongbing (HLB) is a devastating citrus disease associated with Candidatus Liberibacter asiaticus (CLas) and is transmitted by the psyllid Diaphorina citri Kuwayama. Diaphorina citri belongs to Hemiptera order, which has cysteine peptidases as the most abundant proteolytic enzymes present in digestive tract. As cy...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.070

    authors： Ferrara TFS,Schneider VK,Lima PS,Bronze FS,Machado MFM,Henrique-Silva F,Soares-Costa A,Carmona AK

    更新日期：2020-04-30 00:00:00

  • Single stage batch adsorber design for efficient Eosin yellow removal by polyaniline coated ligno-cellulose.

    abstract：:Polyaniline-coated lignin-based adsorbent (PLC) was synthesized and used for uptake of reactive dye eosin yellow (EY) from aqueous solution. The adsorption capability of the adsorbent was found to be more effective than the unmodified adsorbent (LC). In particular, the adsorption capability of the PLC was effective ov...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.09.018

    authors： Debnath S,Ballav N,Maity A,Pillay K

    更新日期：2015-01-01 00:00:00

  • Nitric oxide-releasing chitosan film for enhanced antibacterial and in vivo wound-healing efficacy.

    abstract：:Nitric oxide (NO) is a promising therapeutic agent with antibacterial and wound-healing properties. However, the gaseous state and short half-life of NO necessitate a formulation that can control its storage and release. In this study, we developed NO-releasing films (CS/NO film) composed of chitosan (CS) and S-nitros...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.04.073

    authors： Kim JO,Noh JK,Thapa RK,Hasan N,Choi M,Kim JH,Lee JH,Ku SK,Yoo JW

    更新日期：2015-08-01 00:00:00

  • Biodistribution profiling of the chemical modified hyaluronic acid derivatives used for oral delivery system.

    abstract：:A series of adipic acid dihydrazide (ADH)-modified hyaluronic acid (HA-ADH) compounds were synthesized and conjugated with QDots (QDots-HA conjugates) to assess the effects of the molecular weight (MW) and extent of chemical modification of HA on its biodistribution. Their physicochemical structures were confirmed by ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.11.027

    authors： Hsieh CM,Huang YW,Sheu MT,Ho HO

    更新日期：2014-03-01 00:00:00

  • Lactic acid oligomer (OLLA) grafted gum arabic based green adhesive for structural applications.

    abstract：:L-Lactic acid (LA)-grafted-gum arabic (GA) graft copolymer [OLLA-g-GA] was prepared by using microwave heating in which the hydrophilic GA was grafted with insitu grown lactic acid oligomer. The grafting at OH and NH groups in GA backbone with oligo-(l-lactic acid) (OLLA) chains proved with the help of FTIR and NMR an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.199

    authors： Tripathi N,Katiyar V

    更新日期：2018-12-01 00:00:00

  • Effect of storage and drying temperature on the gelation behavior and structural characteristics of sericin.

    abstract：:Owing to unique properties, including the wound healing effect, sericin gel and films have attracted significant attention in the biomedical and cosmetic fields. The structural characteristics and properties of sericin gels and films are especially important owing to their effect on the performance of sericin in biome...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.09.016

    authors： Jo YN,Park BD,Um IC

    更新日期：2015-11-01 00:00:00

  • Myelin basic protein: structural characterization of spherulites formation and preventive action of trehalose.

    abstract：:Myelin basic protein (MBP) is one of the main protein components of central nervous system that as shown in our work, under appropriate condition, forms spherulites. The structural and morphological features of these elements and the ability of trehalose to decrease or completely avoid their formation have been clarif...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.02.022

    authors： Di Salvo C,Barreca D,Laganà G,di Bella M,Tellone E,Ficarra S,Bellocco E

    更新日期：2013-06-01 00:00:00

  • Molecular docking and in vitro studies of soap nut trypsin inhibitor (SNTI) against phospholipase A2 isoforms in therapeutic intervention of inflammatory diseases.

    abstract：:Therapeutic value of allelochemicals in inflammatory disorders and the potential drug targets need to be elucidated to alleviate tissue and vascular injury. Natural anti-inflammatory agents are known to cause minimal adverse effects. Presence of different secondary metabolites (allelochemicals), protease inhibitors li...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.03.139

    authors： Sirisha GVD,Vijaya Rachel K,Zaveri K,Yarla NS,Kiranmayi P,Ganash M,Alkreathy HM,Rajeh N,Ashraf GM

    更新日期：2018-07-15 00:00:00

  • Synthetic biology approaches: Towards sustainable exploitation of marine bioactive molecules.

    abstract：:The discovery of genes responsible for the production of bioactive metabolites via metabolic pathways combined with the advances in synthetic biology tools, has allowed the establishment of numerous microbial cell factories, for instance the yeast cell factories, for the manufacture of highly useful metabolites from r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2018.01.149

    authors： Seghal Kiran G,Ramasamy P,Sekar S,Ramu M,Hassan S,Ninawe AS,Selvin J

    更新日期：2018-06-01 00:00:00

  • pH dependent green synthesis of gold nanoparticles by completely C6-carboxylated curdlan under high temperature and various pH conditions.

    abstract：:A C6-carboxylated curdlan (C6-Cc) obtained from 4-acetamido-TEMPO-mediated oxidation of curdlan was used both as a reducing and stabilizing agent for green synthesis of pH-responsive AuNPs, which was carried out by controlling the pH of the C6-Cc solution at a high temperature (100°C). C6-Cc presented a semi-flexible ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.08.029

    authors： Qiu WY,Wang K,Wang YY,Ding ZC,Wu LX,Cai WD,Yan JK

    更新日期：2018-01-01 00:00:00

  • Promising alternative gum: Extraction, characterization, and oxidation of the galactomannan of Cassia fistula.

    abstract：:Galactomannan extracted from Cassia fistula seed endosperm present little data related to the its structural characterization. This study reports the chemical characterization of the galactomannan from Cassia fistula (CF) and their oxidized derivatives. The extracted CF presented a yield of 26.5% (w/w) and the intrins...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.164

    authors： da Silva LM,Araújo LFS,Alvez RC,Ono L,Sá DAT,da Cunha PLR,Monteiro de Paula RC,Maciel JS

    更新日期：2020-12-15 00:00:00

  • Structure and hypoglycemic activity of a novel exopolysaccharide of Cordyceps militaris.

    abstract：:A novel neutral exopolysaccharide (EPS-III) was isolated from culture broth of Cordyceps militaris (C. militaris). The EPS-III was a homogeneous polysaccharide with Mw of 1.56 × 103 kDa. The yield of EPS-III from culture broth was 123.2 ± 3.1 mg/L and the sugar content was 93.32 ± 0.87%. The backbone of EPS-III was ma...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.10.207

    authors： Sun H,Yu X,Li T,Zhu Z

    更新日期：2021-01-01 00:00:00

  • Deciphering the interactions of fish gelatine and hyaluronic acid in aqueous solutions.

    abstract：:The interactions of fish gelatine (FG) with hyaluronic acid (HA) are studied in an aqueous environment at 25°C by turbidimetric titration, confocal scanning laser microscopy, dynamic light scattering, zeta potentiometry, spectrophotometry with methylene blue, and construction of state diagrams. FG forms soluble comple...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.04.083

    authors： Razzak MA,Kim M,Kim HJ,Park YC,Chung D

    更新日期：2017-09-01 00:00:00

  • Artificial chaperones based on thermoresponsive polymers recognize the unfolded state of the protein.

    abstract：:Stabilization of the enzymes under stress conditions is of special interest for modern biochemistry, bioengineering, as well as for formulation and target delivery of protein-based drugs. Aiming to achieve an efficient stabilization at elevated temperature with no influence on the enzyme under normal conditions, we st...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.031

    authors： Semenyuk P,Tiainen T,Hietala S,Tenhu H,Aseyev V,Muronetz V

    更新日期：2019-01-01 00:00:00

  • Long non-coding RNA EPIC1 inhibits viability and invasion of osteosarcoma cells by promoting MEF2D ubiquitylation.

    abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) can modulate gene expression through different mechanisms, but the fundamental molecular mechanism behind EPIC1 and osteosarcoma (OS) was poorly understood. METHODS:Bone tumor tissues and the matched normal tissues were obtained from 36 OS patients who received tumor resection...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.01.156

    authors： Zhao W,Zhang D,Qin P,Zhang J,Cui X,Gao J,Wang J,Li J

    更新日期：2019-05-01 00:00:00

  • Single crystals of V amylose complexed with glycerol.

    abstract：:Lamellar single crystals of amylose V glycerol were grown at 100 degrees C by evaporating water from solutions of amylose in aqueous glycerol. The crystals which were square, with lateral dimensions of several micrometers, gave sharp electron diffraction patterns presenting an orthorhombic symmetry with a probable spa...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(95)01069-6

    authors： Hulleman SH,Helbert W,Chanzy H

    更新日期：1996-02-01 00:00:00

  • Effect of chitin/silk fibroin nanofibrous bicomponent structures on interaction with human epidermal keratinocytes.

    abstract：:To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water v...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.12.004

    authors： Yoo CR,Yeo IS,Park KE,Park JH,Lee SJ,Park WH,Min BM

    更新日期：2008-05-01 00:00:00

  • Gamma radiation-induced preparation of chitosan-acrylic acid-1-vinyl-2-vinylpyrrolidone/multiwalled carbon nanotubes composite for removal of 152+154Eu, 60Co and 134Cs radionuclides.

    abstract：:Removal behaviors of 152+154Eu, 60Co, and 134Cs radionuclides onto Chitosan-acrylic acid-1-vinyl-2-vinylpyrrolidone/oxidized multi-walled carbon nanotubes (CTS-AA-VP/o-MWCNTs) composite has been investigated by batch adsorption technique. CTS-AA-VP/o-MWCNTs composite has been synthesized by copolymerization of acrylic...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.08.120

    authors： Abdelmonem IM,Metwally E,Siyam TE,Abou El-Nour F,Mousa AM

    更新日期：2020-12-01 00:00:00

  • Antiplatelet and antithrombotic activity of a fibrin(ogen)olytic protease from Bacillus cereus strain FF01.

    abstract：:Fibrin(ogen)olytic enzymes offer great promise for the treatment of thrombosis associated disorders. The present study describes the characterization of an extracellular fibrin(ogen)olytic serine protease (named Bacethrombase) purified from the Bacillus cereus strain FF01. The molecular mass of the Bacethrombase was d...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.04.075

    authors： Majumdar S,Dutta S,Das T,Chattopadhyay P,Mukherjee AK

    更新日期：2015-08-01 00:00:00