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Nitric oxide-releasing chitosan film for enhanced antibacterial and in vivo wound-healing efficacy.

Abstract：

:Nitric oxide (NO) is a promising therapeutic agent with antibacterial and wound-healing properties. However, the gaseous state and short half-life of NO necessitate a formulation that can control its storage and release. In this study, we developed NO-releasing films (CS/NO film) composed of chitosan (CS) and S-nitrosoglutathione (GSNO) as a NO donor. Thermal analysis demonstrated molecular dispersion of GSNO in the films. In vitro release study revealed that NO release from CS/NO films followed Korsmeyer-Peppas model with Fickian diffusion kinetics. Moreover, the CS/NO film showed a stronger antibacterial activity against Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive) than the CS film. Further, the CS/NO film accelerated wound healing and epithelialization in a rat model of full-thickness wounds as compared to the CS film. Histopathological studies revealed that CS/NO films favorably enhanced the re-epithelialization and reconstruction of wounded skin. Therefore, our results suggest that CS/NO films could be a suitable formulation for treating full-thickness wounds.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Kim JO,Noh JK,Thapa RK,Hasan N,Choi M,Kim JH,Lee JH,Ku SK,Yoo JW

doi

10.1016/j.ijbiomac.2015.04.073

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

217-25

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)00311-6

journal_volume

79

pub_type

杂志文章

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