当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs.

Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs.

Abstract：

:In recent years, aging has been reported to be regulated by HAT. In this study, the inhibitory effects of spermidine on the matrix metalloproteinase-2 (MMP-2) activity and expression were investigated in human dermal fibroblasts (HDFs). It was observed that spermidine inhibits MMP-2 activity and expression. In addition, the expression levels of histone acetyltransferase (HAT), phospho-extracellular-signal related kinase (p-ERK), phospho-c-jun N-terminal kinase (p-JNK), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) are decreased in the presence of spermidine. In contrast, the expression levels of histone deacetylase 1 (HDAC1), sirtuin 1 (SIRT1), phospho-p38 (p-p38) are increased by spermidine. In conclusion, our results suggest that spermidine could have a therapeutic potential in inhibition of metastasis through the inhibitory effects on activity and expression of MMP-2 via regulation of HAT and HDAC.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Park IH,Kim MM

doi

10.1016/j.ijbiomac.2012.08.013

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1003-7

issue

5

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(12)00329-7

journal_volume

51

pub_type

杂志文章

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