Collagen organization in an oriented fibrous capsule.

Abstract:

:X-ray diffraction and polarized light microscopy studies were carried out on a fibrous capsule to examine the collagen organization produced in a granuloma response. The capsule had been formed around a silicone tube covered with polyester mesh following implantation in a sheep. The fibrous capsule has previously been shown to include a substantial amount of type III collagen, in addition to type I collagen. Whereas granulomas generally show little order, the sample in the present study has a high degree of orientation of the collagen fibrils along the tube direction. X-ray diffraction patterns of the capsule showed an axial D period near 65 nm, a value similar to that of other type III collagen-containing tissues. This axial period is less than the 67 nm period seen in tendon and bone, which contain only type I collagen. The decreased D period is consistent with an increase in the tilting of the collagen molecules with respect to the fibril axis.

journal_name

Int J Biol Macromol

authors

Brodsky B,Ramshaw JA

doi

10.1016/0141-8130(94)90007-8

subject

Has Abstract

pub_date

1994-02-01 00:00:00

pages

27-30

issue

1

eissn

0141-8130

issn

1879-0003

pii

0141-8130(94)90007-8

journal_volume

16

pub_type

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