Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan.

Abstract:

:The purpose of this study was to develop a new therapeutic approach for atorvastatin (ATV) adopting nanostructured polymeric micelles for its controlled delivery to the cancer cells. Amphiphilic block copolymers of stearyl chitosan (SC) and sulfated stearyl chitosan (S-SC) that could self assemble to form polymeric micelles with different degree of substitution (DS) were synthesized and characterized. The synthesized chitosan derivatives were able to self assemble and form micelles encapsulating ATV with critical micellar concentrations ranging from 6.9 to 21μg/ml, drug-loading ranging from 40% to 84.1% and encapsulation efficiency ranging from 10.4% to 35%. ATV caused a significant decrease in particle size and zeta potential of both SC and S-SC micelles. Micelles encapsulating ATV exhibited a sustained release and more cytotoxic activity against MCF 7 and HCT 116 cell lines than ATV alone. The 50% cellular growth inhibition (IC50%) of the drug decreased from 10.4 to 3.7 in case of MCF 7 and from 9.4 to 3.4 in case of HCT 116 after its loading in micelles. These results indicate that SC ATV polymeric micelles can be considered as a promising system for site specific controlled delivery of ATV to tumor cells.

journal_name

Int J Biol Macromol

authors

Mekhail GM,Kamel AO,Awad GA,Mortada ND

doi

10.1016/j.ijbiomac.2012.05.026

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

351-63

issue

4

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(12)00197-3

journal_volume

51

pub_type

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