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The effects of daunomycin antibiotic on histone H(1): thermal denaturation and fluorescence spectroscopy studies.

Abstract：

:Using thermal denaturation and fluorescence spectroscopy, we have investigated the interaction of antitumor antibiotic, daunomycin, with calf thymus histone H(1) under several ionic strengths. The results show that daunomycin binds to histone H(1) and increases its melting temperature. Increasing ionic strength elevates this effect. Fluorescence emission data show that the interaction of daunomycin with histone H(1) decreases the emission intensity at 325 nm and induces hyperchromicity in the emission spectrum of the drug. The results suggest that histone H(1) can be considered as a new target for drug action at the chromatin level.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zargar SJ,Rabbani A

doi

10.1016/s0141-8130(00)00146-x

keywords:

subject

Has Abstract

pub_date

2000-10-10 00:00:00

pages

75-9

issue

1

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(00)00146-X

journal_volume

28

pub_type

杂志文章

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