当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics.

Design and development of Albizia stipulata gum based controlled-release matrix tablets in cancer therapeutics.

Abstract：

:The present study deals with the development of natural macromolecule gum Albizia stipulata (AS) based novel pharmaceutical excipient for the controlled-release of paracetamol (PC). Central composite design (CCD) two-factor, five-level was used for the optimization of independent variables AS gum and compression force (CF) based on desired response variable drug release (DR) of paracetamol matrix tablets (PCMT). The optimized PCMT was prepared by wet granulation method and screened for pre- and post- compression parameters, and were characterized. The optimized PCMT (F14) formulation showed favorable in vitro release of PC (65%) in 12h, and the release kinetics followed zero order anomalous diffusion mechanism. AS gum exerted significant (p<0.001) anticancer activity with 98.25% inhibition at 2000μg/mL (IC50=179.12μg/mL) against A549 cell line. PC and PCMT showed 78.56% inhibition (IC50 value=856.58μg/mL) and 93.68% inhibition (IC50 value=396.35μg/mL) respectively, symbolizing that the gum remarkably potentiated the anticancer effect of PC in formulation after 24h treatment by inducing apoptosis. This is the first report on A. stipulata gum as a promising biopolymer for drug delivery application in cancer therapeutics.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

T VS,Henry LJ,Narra K,Lalduhsanga P,Kandasamy R

doi

10.1016/j.ijbiomac.2016.08.006

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

972-980

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)31107-2

journal_volume

92

pub_type

杂志文章

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