Abstract：
:Mucoadhesive molecules such as chitosan, can allow targeting of a particular tissue to prolong residence time and subsequently improve bioavailability. The purpose of this study was to investigate chitosan-tripolyphosphate (CS:TPP) nanoparticles and to evaluate the interaction between nanoparticles of different CS:TPP ratios with mucin using viscosity, particle size analysis and ζ-potential. For all CS:TPP ratios examined, a minimum value of viscosity was reached for a 3:1 CS:TPP ratio, however chitosan nanoparticles at this ratio were not stable (<+30 mV), whereas a CS:TPP ratio of 4:1 displayed the strongest interaction. This suggests a minimum CS:TPP ratio of 4:1 is required to produce stable nanoparticles able to form strong interactions, which is consistent with a greater mucin binding efficiencies at CS:TPP ratios of 4:1 and higher, which were quantified using a colorimetric assay. Further analysis of similar systems could lead potentially to tuneable chitosan nanoparticles for specific applications.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Hejjaji EMA,Smith AM,Morris GAdoi
10.1016/j.ijbiomac.2018.09.185subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1610-1617issue
Pt Beissn
0141-8130issn
1879-0003pii
S0141-8130(18)34046-7journal_volume
120pub_type
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章,评审
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章,评审
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2012.04.021
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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更新日期：2020-06-15 00:00:00
