Abstract：
:Chitosan (CS) is a well-known biological macromolecule having numerous applications due to its exceptional properties especially in the form of nanofibers. The antibacterial activity is compromised when co-polymers are added to electrospun CS but, the reproducibility can be enhanced which is key to commercialization. We have tried to enhance the antibacterial activity of chitosan based nanofibers with the addition of Zinc oxide (ZO) nanoparticles and ciprofloxacin (model drug) at very low concentrations. The rheology of solutions was studied along with the process parameters for the optimization of nanofibers using response surface methodology. Nanofibers having diameter of 116 nm with a SD of only 21 nm were optimized. ZO loaded nanofibers showed better thermal stability. Different drug release models were fitted to drug release profile. The release was pH dependent best followed by Zero order and Hixson Crowell release models. Good antibacterial activity and non-toxicity was observed against human dermal fibroblast and keratinocytes cell lines (>82.5%) which justifies its potential to eliminate or prevent infection in burn wounds with less side effects due to low amount of drug.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Abid S,Hussain T,Nazir A,Zahir A,Ramakrishna S,Hameed M,Khenoussi Ndoi
10.1016/j.ijbiomac.2019.06.022subject
Has Abstractpub_date
2019-08-15 00:00:00pages
1222-1236eissn
0141-8130issn
1879-0003pii
S0141-8130(19)31750-7journal_volume
135pub_type
杂志文章abstract：:Cyclina sinensis is an edible clam widely distributed along the coastal waters of Asia. In the present study, a polysaccharide (CSP-1) isolated from C. sinensis was purified by a DEAE-Sepharose Fast Flow column, and it had an average molecular weight of 3.8 × 105 Da and a prevalent component monosaccharide of Glc. The...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2015.11.003
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2018-12-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章,评审
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abstract：:Controlled release of antimicrobial and antioxidant compounds from packaging films is of utmost importance for extending the shelf-life of perishable foods. This study focused on the mathematical modeling of gallic acid release into an aqueous medium from three chitosan films, formulated with grape seed extract (GSE) ...
journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2019.06.048
更新日期：2019-09-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2016.10.064
更新日期：2017-01-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2018.07.032
更新日期：2018-11-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2018.08.163
更新日期：2018-12-01 00:00:00
abstract：:Uncontrolled bleeding is an important cause of military and civilian casualties. GO has received more attention in the field of hemostasis. However, pure GO has various limitation in application due to its potential thrombosis, hemolytic and cytotoxicity. Herein, we present a simple, rapid and low-cost method to combi...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2019.02.137
更新日期：2019-06-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2008.08.012
更新日期：2008-12-01 00:00:00
abstract：:This review summarizes some of the results obtained from the crystal structure determination of viruses. The structural similarities of viral coat proteins is discussed, as well as some structural results related to the regulation of viral disassembly. ...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/0141-8130(91)90026-q
更新日期：1991-10-01 00:00:00
abstract：:Biodegradable poly-3-hydroxybutyrate [P(3HB)] and natural fillers - clay, peat, and birch wood flour - were used to prepare powdered composites to form pellets and granules. Pellets were produced by cold pressing of polymer and filler powder whereas granules were produced from the powders wetted with ethanol. Characte...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2020-07-15 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2012.04.021
更新日期：2012-07-01 00:00:00
abstract：:Nanogenerator is a promising energy harvesting device that can scavenge tiny mechanical energy from the surrounding environment, and then convert it into electricity. Natural bio-polymers are the potential candidates for the design of nanogenerators due to their excellent characteristics like piezoelectricity, triboel...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章,评审
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abstract：:Papain enzyme was successfully immobilized by covalent bonding onto biocompatible Fe3O4/SF nanoparticles, which were prepared with the soft template of silk fibroin (SF). The optimized immobilization condition is pH6.0, hydrolysis time of 60min, and an enzyme/support ratio of 10.0mg/g. Compared with free papain, the i...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2018-07-15 00:00:00
abstract：:Jambo is a tropical fruit cultivated in Southeast Asia and tropical regions of America and Africa. After extraction, its polysaccharides were structurally characterized. Water soluble polysaccharides (WSP) were composed of GalA:Ara:Gal:Glc:Rha in 51:22:16:5:6 molar ratio, indicating the presence of pectic polysacchari...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2018-10-15 00:00:00
abstract：:One water-soluble neutral polysaccharides (NPs), with an average molecular weight of 5.77 × 103 Da, was isolated from bamboo (Phyllostachys pubescens Mazel) leaves and the yield was 10.2% based on weight of raw material. Successively, two fractions (NPs-A and NPs-B) could be obtained after being eluted by DEAE-Sepharo...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2012.03.017
更新日期：2012-06-01 00:00:00
abstract：:In this study, chitosan oligosaccharide (COS) was modified by grafting Linalool (Lin) on its backbone to improve its anti-inflammatory activity. By changing the molar ratios of COS to Lin, three different degrees of substitution COS-g-Lin1-3 were prepared. The degrees of substitution of derivatives were 0.65, 0.80 and...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2020.11.036
更新日期：2021-01-01 00:00:00
abstract：:Bacteriocins are bioactive antimicrobial peptides synthesized in the ribosome of numerous bacteria and released extracellularly. Bacteriocins have the ability to kill or inhibit the growth of prokaryotes and could potentially be useful against pathogens and antibiotic-resistant strains of bacteria. The antimicrobial m...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章,评审
doi：10.1016/j.ijbiomac.2018.05.233
更新日期：2018-10-01 00:00:00
abstract：:Lysyl oxidase (LOX) is an extra-cellular matrix-modifying enzyme that has been linked to cell proliferation, metastasis, angiogenesis and wound healing. This study was designed to examine the association of LOX gene polymorphism G473A, G>A, (rs1800449) located in exon 1 of the LOX gene in diabetic subjects with and wi...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
doi：10.1016/j.ijbiomac.2017.05.050
更新日期：2017-10-01 00:00:00
