当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein.

Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein.

Abstract：

:The Notch signaling pathway (NSP) is an important intercellular communication mechanism that regulates embryo development and adult physiological functions. The Hairless (H) protein is a powerful antagonist of the NSP by its interaction with the Suppressor of Hairless (Su[H]) protein, recruiting the corepressors Gro and CtBP. In the present work, we examined the role of several important amino acids in different H protein domains analyzing four mutant lines of Drosophila melanogaster. The mutant alleles were evaluated by single-strand conformational polymorphism (SSCP) analysis and we located mutated regions at different positions along the sequence of the Hairless gene.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Paz-Gómez D,Baizabal-Aguirre VM,Valdez-Alarcón JJ,Cajero-Juárez M,Nagel AC,Preiss A,Maier D,Bravo-Patiño A

doi

10.1016/j.ijbiomac.2008.08.012

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

426-32

issue

5

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(08)00192-X

journal_volume

43

pub_type

杂志文章

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