Abstract：
:Zein nanoparticles (ZNPs) have limited use as a result of its poor colloidal stability. The goal of this paper is to stabilize ZNPs using a sulfated anionic polysaccharide-dextran sulfate (DS). Zein/DS composite nanoparticles (ZDSNPs) were fabricated by antisolvent precipitation method at pH 4.0 with an optimal zein-to-DS ratio of 1:2 (w/w). ZDSNPs exhibited good stability to pH, heating and storage. Additionally, ZDSNPs showed spherical structures formed primarily by electrostatic attractions, hydrogen bonding and hydrophobic interactions. The incorporation of DS led to the change in secondary structure of zein. The surface hydrophobicity of ZNPs reduced owing to the deposition of DS. And ZDSNPs were basically nontoxic to normal colonic epithelial cell lines-NCM460 cell lines. ZDSNPs were successfully used to encapsulate curcumin. The encapsulation efficiency of curcumin-loaded ZDSNPs (ZDSCNPs) was 85.37%, which was significantly higher than that of curcumin-loaded ZNPs. In addition, ZDSCNPs exhibited improved storage stability and bioaccessibility of curcumin.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Yuan Y,Li H,Zhu J,Liu C,Sun X,Wang D,Xu Ydoi
10.1016/j.ijbiomac.2019.10.149subject
Has Abstractpub_date
2020-05-15 00:00:00pages
1074-1083eissn
0141-8130issn
1879-0003pii
S0141-8130(19)36024-6journal_volume
151pub_type
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