Abstract:
:The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Ouyang QQ,Hu Z,Lin ZP,Quan WY,Deng YF,Li SD,Li PW,Chen Ydoi
10.1016/j.ijbiomac.2018.01.217subject
Has Abstractpub_date
2018-06-01 00:00:00pages
1191-1198eissn
0141-8130issn
1879-0003pii
S0141-8130(17)35000-6journal_volume
112pub_type
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journal_title:International journal of biological macromolecules
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