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Structural characterization and anticomplement activity of an acidic polysaccharide from Hedyotis diffusa.

Abstract：

:An acidic homogeneous polysaccharide (HD-PS-1) was purified from Hedyotis diffusa (Willd.) Roxb. HD-PS-1 possessed a backbone chain of →[4)-β-Glcp-3-OAc-(1]6→[6)-β-Manp-(1]2→6)-α-Galp-(1→[4)-α-Galp-(1]2→, with three branches of β-Manp-(1→3)-β-GlcpA, α-Rhap-(1→3)-α-Rhap and α-Galp attached to the backbone chain at O-4 position of 1,4,6-linked β-Manp, O-3 position of 1,3,6-linked α-Galp and O-3 position of 1,3,4-linked α-Galp, respectively. HD-PS-1 exhibited significant anticomplement activity (CH50: 0.084 ± 0.009 mg/mL, AP50: 0.176 ± 0.013 mg/mL). It was found that the presence of uronic acids is important to anticomplement activity of HD-PS-1, given that the reduced HD-PS-1 showed weaker activity (CH50: 0.456 ± 0.008 mg/mL, AP50: 0.572 ± 0.010 mg/mL). Preliminary mechanism study indicated that HD-PS-1 interacted with C3 and C4 in the complement activation cascade. In addition, a neutral homogeneous polysaccharide (HD-PS-2) was also purified and characterized. HD-PS-2 displayed antioxidant activity by scavenging DPPH· radicals without anticomplement activity.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Huo J,Lu Y,Jiao Y,Chen D

doi

10.1016/j.ijbiomac.2019.11.132

subject

Has Abstract

pub_date

2020-07-15 00:00:00

pages

1553-1560

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)33416-6

journal_volume

155

pub_type

杂志文章

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