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Adjustable 'cross-linking' of neighboring DNA molecules in liquid-crystalline dispersions through (daunomycin-copper) polymeric chelate complexes.

Abstract：

:The interaction of daunomycin molecules with double-stranded DNA in the liquid-crystalline state was investigated. It was shown that at a certain extent of daunomycin binding a change of the mechanism of anthracycline orientation with reference to the DNA chain occurs. This is testified by the alteration of the sense of spatial packing of the DNA molecules in liquid-crystalline dispersions formed as a result of phase separation in poly(ethyleneglycol)-containing solutions, as well as by the onset of the reaction of daunomycin with divalent copper ions. Using this reaction, polymeric (daunomycin-copper) chelate cross-links between the DNA molecules fixed in the liquid-crystalline dispersions were formed. The length of such cross-links as adjusted by the distance between the DNA molecules, which, in turn, depends on the concentration of poly(ethyleneglycol) used for phase separation. The above molecular building mechanism may lead to new interesting applications.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Yevdokimov YM,Salyanov VI,Spener F,Palumbo M

doi

10.1016/s0141-8130(96)01134-8

subject

Has Abstract

pub_date

1996-12-01 00:00:00

pages

247-55

issue

4

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(96)01134-8

journal_volume

19

pub_type

杂志文章

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