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Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans.

Abstract：

:In this study, three different carboxymethyl chitosans (CMCs), namely O-carboxymethyl chitosan (OC), N-carboxymethyl chitosan (NC) and N,O-carboxymethyl chitosan (NOC), were prepared as nano-carriers for an anti-tumor drug, docetaxel (DCT). Three CMCs were fabricated into drug-loading nanoparticles under different preparing conditions respectively. A series of characterization parameters were determined including drug loading capacity (DC), entrapment efficiency (EE), particle size distribution, zeta potential, and morphology, which were used to find the optimized preparing condition for three kinds of nanoparticles (NPs). Furthermore, the in vitro drug release profiles of all the three kinds of nanoparticles showed a sustained release behavior and the release rate of OC-NPs was the fastest. Moreover, compared with NC-NPs and NOC-NPs, OC-NPs exhibited more cellular accumulation in the human gastric carcinoma cells (SGC 7901) as quantitatively determined by the flow cytometry and also much stronger cytotoxicity against these cells. Accordingly, our results showed that drug-loaded nanoparticles formed by different CMCs have dissimilar physiochemical characteristics which subsequently influence their therapeutic effects. We suggest that OC-based nanoparticle is a more desirable anti-tumor drug delivery system than NC-NP and NOC-NP.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zhang E,Xing R,Liu S,Li K,Qin Y,Yu H,Li P

doi

10.1016/j.ijbiomac.2017.03.195

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

1012-1018

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)30283-0

journal_volume

101

pub_type

杂志文章

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