当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Ganoderma atrum polysaccharide ameliorates anoxia/reoxygenation-mediated oxidative stress and apoptosis in human umbilical vein endothelial cells.

Ganoderma atrum polysaccharide ameliorates anoxia/reoxygenation-mediated oxidative stress and apoptosis in human umbilical vein endothelial cells.

Abstract：

:Ganoderma atrum polysaccharide (PSG-1), a main polysaccharide from Ganoderma atrum, possesses potent antioxidant capacity and cardiovascular benefits. The aim of this study was to investigate the role of PSG-1 in oxidative stress and apoptosis in human umbilical vein endothelial cells (HUVECs) under anoxia/reoxygenation (A/R) injury conditions. The results showed that exposure of HUVECs to A/R triggered cell death and apoptosis. Administration of PSG-1 significantly inhibited A/R-induced cell death and apoptosis in HUVECs. PSG-1-reduced A/R injury was mediated via mitochondrial apoptotic pathway, as evidenced by elevation of mitochondrial Bcl-2 protein and mitochondrial membrane potential, and attenuation of Bax translocation, cytochrome c release and caspases activation. Furthermore, PSG-1 enhanced the activities of superoxide dismutase, catalase and glutathione peroxidase and glutathione content, and concomitantly attenuated reactive oxygen species generation, lipid peroxidation and glutathione disulfide content. The antioxidant, N-acetyl-l-cysteine, significantly ameliorated all of these endothelial injuries caused by A/R, suggesting that antioxidant activities might play a key role in PSG-1-induced endothelial protection. Taken together, these findings suggested that PSG-1 could be as a promising adjuvant against endothelial dysfunction through ameliorating oxidative stress and apoptosis.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zhang YS,Li WJ,Zhang XY,Yan YX,Nie SP,Gong DM,Tang XF,He M,Xie MY

doi

10.1016/j.ijbiomac.2017.01.071

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

398-406

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)31983-3

journal_volume

98

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Insight into the role of integrated carbohydrate polymers (starch, chitosan, and β-cyclodextrin) with mesoporous silica as carriers for ibuprofen drug; equilibrium and pharmacokinetic properties.

    abstract：:Three types of carbohydrate polymers starch (ST), chitosan (CH), and β-cyclodextrin (β-CD) were integrated with mesoporous silica (MCM-48) in some biopolymers nanocomposites (MCM-48/ST, MCM-48/CH, MCM-48/β-CD) as promising delivery systems for ibuprofen drug. This was conducted by simple mixing of the polymers gels wi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.052

    authors： Abukhadra MR,Refay NM,Nadeem A,El-Sherbeeny AM,Ibrahim KE

    更新日期：2020-08-01 00:00:00

  • Effect of o-acyl substituents on the functional behaviour of Rhizobium meliloti succinoglycan.

    abstract：:The effects of selective removal of acetyl or succinyl substituents on the functionality of succinoglycan polysaccharide have been studied by comparing the behaviour of the polysaccharides isolated from native Rhizobium meliloti strain Rm1021, and genetically modified R. meliloti species. Removal of the succinyl group...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(96)01140-3

    authors： Ridout MJ,Brownsey GJ,York GM,Walker GC,Morris VJ

    更新日期：1997-02-01 00:00:00

  • Synthesis of gum kondagogu-g-poly(N-vinyl-2-pyrrolidone) and its evaluation as a mucoadhesive polymer.

    abstract：:The purpose of the present study was to synthesize gum kondagogu-g-poly(N-vinyl-2-pyrrolidone) and to evaluate its mucoadhesive properties. UV-assisted graft co-polymerization of N-vinyl-2-pyrrolidone on gum kondagogu was carried out employing three-factor, three-level central composite experimental designs. It was ob...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.07.009

    authors： Malik S,Kumar A,Ahuja M

    更新日期：2012-12-01 00:00:00

  • Comparative effects of limited tryptic hydrolysis on physicochemical and structural features of seed 11S globulins.

    abstract：:The effect of the limited proteolysis by trypsin on selected seed storage 11S globulins (broad bean and pea legumins, glycinin and helianthinin) was studied by high-sensitive differential scanning calorimetry, fluorescence spectroscopy and analysis of proteolysis kinetics. Different behaviour of glycinin and helianthi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.12.006

    authors： Braudo EE,Danilenko AN,Guslyannikov PV,Kozhevnikov GO,Artykova GP,Lapteva NA,Vaintraub IA,Sironi E,Duranti M

    更新日期：2006-11-15 00:00:00

  • Overcoming stemness and chemoresistance in colorectal cancer through miR-195-5p-modulated inhibition of notch signaling.

    abstract：:MiR-195-5p has been shown to have a regulatory role in a variety of cancers. Its influence on colorectal cancer (CRC), however, has never been evaluated. In the present study, we found that miR-195-5p expression was significantly decreased as compared to paired, tumor-adjacent normal colorectal tissues. We demonstrate...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.151

    authors： Jin Y,Wang M,Hu H,Huang Q,Chen Y,Wang G

    更新日期：2018-10-01 00:00:00

  • Preparation of fish gelatin and fish gelatin/poly(L-lactide) nanofibers by electrospinning.

    abstract：:Ultrafine fibers were successfully fabricated from Channel catfish skin-extracted gelatin via electrospinning (ES). Important ES parameters, such as concentration of aqueous acid and fish gelatin solutions, and electric field intensity were examined to investigate the effects on the morphology of the gelatin nanofiber...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.06.002

    authors： An K,Liu H,Guo S,Kumar DN,Wang Q

    更新日期：2010-10-01 00:00:00

  • Bufadienolides from Kalanchoe daigremontiana modulate the enzymatic activity of plasmin - In vitro and in silico analyses.

    abstract：:Plasmin (EC 3.4.21.7) is a key enzyme of the fibrinolytic system, responsible for the degradation of fibrin clot and maintaining blood fluidity. Hence, alterations of the fibrinolytic capacity of blood plasma may contribute to thrombotic or bleeding complications. The aim of this study was to determine effects of a bu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.143

    authors： Kolodziejczyk-Czepas J,Pasiński B,Ponczek MB,Moniuszko-Szajwaj B,Kowalczyk M,Pecio Ł,Nowak P,Stochmal A

    更新日期：2018-12-01 00:00:00

  • Interaction of heat shock protein 90 B1 (Hsp90B1) with liposome reveals its potential role in protection the integrity of lipid membranes.

    abstract：:Heat shock proteins of 90kDa (Hsp90) are molecular chaperones essential for protein homeostasis. Besides chaperone activity, Hsp90 exhibits other cellular functions at membranes, yet how it interacts with membranes remains elusive. We report here that Hsp90B1 interacts with phospholipid membranes. We first cloned the ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.08.121

    authors： Li P,Zhang M,Zou Y,Sun Z,Sun C,Geng Z,Xu W,Wang D

    更新日期：2018-01-01 00:00:00

  • Ovotransferrin enhances intestinal immune response in cyclophosphamide-induced immunosuppressed mice.

    abstract：:Ovotransferrin (OVT), a glycoprotein from avian egg, which has a variety of biological activities and immunomodulatory effects. The purpose of this research was to demonstrate the effect of OVT on intestinal immunomodulatory function which used a mouse model of cyclophosphamide (CP) induced intestinal immunosuppressio...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.058

    authors： Zhu G,Luo J,Du H,Jiang Y,Tu Y,Yao Y,Xu M

    更新日期：2018-12-01 00:00:00

  • Novel pH-sensitive films based on starch/polyvinyl alcohol and food anthocyanins as a visual indicator of shrimp deterioration.

    abstract：:Intelligent packaging can provide better preservation and advanced convenience for consumers. In this study, corn starch and polyvinyl alcohol (PVA) were used to produce films. Two easily accessible anthocyanin sources-purple sweet potato extracts (PSPE) and red cabbage extracts (RCE), were added respectively to evalu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.159

    authors： Zhang K,Huang TS,Yan H,Hu X,Ren T

    更新日期：2020-02-15 00:00:00

  • DNA binding and nuclease activity of an oxovanadium valinato-Schiff base complex.

    abstract：:A new oxovanadium complex [VO(sal-l-val)(phen)] (sal-l-val=Schiff base derived from salicylaldehyde and l-valine; phen=1,10-phenanthroline) has been designed and synthesized with the aim of developing potential DNA nuclease. The interaction of DNA with this structurally characterized oxovanadium complex has been studi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.02.033

    authors： Saha U,Mukherjea KK

    更新日期：2014-05-01 00:00:00

  • Polymer coated mesoporous ceramic for drug delivery in bone tissue engineering.

    abstract：:Treatment strategy for various bone fracture and defects the researchers are focusing to develop a new carrier for delivering the drug into injured area with controlled and sustained manner using biomaterials with dynamic architecture orientation. Ceramic materials are resembled with bone compositional architecture an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2017.11.146

    authors： Subhapradha N,Abudhahir M,Aathira A,Srinivasan N,Moorthi A

    更新日期：2018-04-15 00:00:00

  • Recent advances on polysaccharides, lipids and protein based edible films and coatings: A review.

    abstract：:Food is a vital product for the survival of human beings and with passage of time quality concerns of consumers are rising. Edible films and coatings are thin layers applied on food products to protect them and improve their quality. Films/coatings are prepared from naturally occurring renewable sources (polysaccharid...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2017.11.097

    authors： Hassan B,Chatha SAS,Hussain AI,Zia KM,Akhtar N

    更新日期：2018-04-01 00:00:00

  • Development of the PVA/CS nanofibers containing silk protein sericin as a wound dressing: In vitro and in vivo assessment.

    abstract：:Skin and soft tissue infections are major concerns with respect to wound repair. Recently, anti-bacterial wound dressings have been emerging as promising candidates to reduce infection, thus accelerating the wound healing process. This paper presents our work to develop and characterize poly(vinyl alcohol) (PVA)/chito...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.139

    authors： Bakhsheshi-Rad HR,Ismail AF,Aziz M,Akbari M,Hadisi Z,Omidi M,Chen X

    更新日期：2020-04-15 00:00:00

  • Microbial serine protease inhibitors and their therapeutic applications.

    abstract：:Serine protease inhibitors, inhibit serine proteases either partially or completely after forming complexes with their respective proteases. Protease actions are significant for many physiological pathways found in living forms and any anomalies may lead to numerous physiological complications. Each cell or organism h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2017.09.115

    authors： Harish BS,Uppuluri KB

    更新日期：2018-02-01 00:00:00

  • Simultaneous co-immobilization of three enzymes onto a modified glassy carbon electrode to fabricate a high-performance amperometric biosensor for determination of total cholesterol.

    abstract：:In this work, we have fabricated a novel amperometric cholesterol (CHO) biosensor because of the importance of determination of CHO levels in blood which is an important parameter for diagnosis and prevention of disease. To achieve this goal, cholesterol oxidase, cholesterol esterase and horseradish peroxidase were si...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.163

    authors： Rashidi K,Mahmoudi M,Mohammadi G,Zangeneh MM,Korani S,Goicoechea HC,Gu HW,Jalalvand AR

    更新日期：2018-12-01 00:00:00

  • Preparation and properties of granular cold-water-soluble porous starch.

    abstract：:In this work, granular cold-water soluble waxy corn starch (N-GCWS) and granular cold-water soluble porous waxy corn starch (P-GCWS) were prepared by waxy corn starch (WS) treated with alcohol-alkali. Starch morphologies, crystal structures, turbidity, cold water viscosity, freeze-thaw stability and oil absorption cap...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.060

    authors： Chen Y,Dai G,Gao Q

    更新日期：2020-02-01 00:00:00

  • Thermal helix-coil transition in UV irradiated collagen from rat tail tendon.

    abstract：:The thermal helix-coil transition in UV irradiated collagen solution, collagen film and pieces of rat tail tendon (RTT) were compared. Their thermal stability's were determined by differential scanning calorimeter (DSC) and by viscometric measurements. The denaturation temperatures of collagen solution, film and piece...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(99)00047-1

    authors： Sionkowska A,Kamińska A

    更新日期：1999-05-01 00:00:00

  • Zinc alginate-carboxymethyl cashew gum microbeads for prolonged drug release: development and optimization.

    abstract：:Isoxsuprine HCl-loaded microbeads using sodium alginate (SA)-carboxymethyl cashew gum (CMCG) polymer-blends were developed through ionotropic-gelation technique using ZnSO4 as cross-linker. Effects of polymer-blend ratio and cross-linker concentration on drug encapsulation efficiency (DEE) and cumulative drug release ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.07.030

    authors： Das B,Dutta S,Nayak AK,Nanda U

    更新日期：2014-09-01 00:00:00

  • Biochemical analysis and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L.

    abstract：:Purification, characterization and hypoglycemic activities of polysaccharide from Lycium barbarum L. were investigated in this study. A water soluble polysaccharide (LBP) was obtained with ultrafiltration membranes separation, which was further purified by chromatography of DEAE cellulose column and Sephadex G-150 to ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.03.026

    authors： Tang HL,Chen C,Wang SK,Sun GJ

    更新日期：2015-01-01 00:00:00

  • NMR studies of succinoglycan repeating-unit octasaccharides from Rhizobium meliloti and Agrobacterium radiobacter.

    abstract：:Complete 1H and 13C-nuclear magnetic resonance assignments have been obtained for the octasaccharide repeating units of the bacterial polysaccharide succinoglycan from Rhizobium meliloti Rm1021 and Agrobacterium radiobacter NCIB 11883. The assignments were used to determine the locations of the O-succinyl and O-acetyl...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(96)81846-0

    authors： Chouly C,Colquhoun IJ,Jodelet A,York G,Walker GC

    更新日期：1995-12-01 00:00:00

  • Cell wall metabolism and autolytic activities of the yeast Saccharomyces exiguus.

    abstract：:Autolytic activities were measured in cell walls prepared from the yeast Saccharomyces exiguus. Walls of yeast cells exhibited higher autolytic activities directed toward glucans at the exponential phase of growth when compared to cells at the stationary phase, while glucanase activities in the soluble extract fractio...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(97)00034-2

    authors： Inouhe M,Sugo E,Tohoyama H,Joho M,Nevins DJ

    更新日期：1997-08-01 00:00:00

  • Development of zolmitriptan loaded PLGA/poloxamer nanoparticles for migraine using quality by design approach.

    abstract：:The purpose of this investigation was to develop Poly (D,L Lactide-co-Glycolide) (PLGA)/poloxamer nanoparticles (NPs) of the hydrophilic drug Zolmitriptan using quality-by-design approach for brain targeting. Randomized 2(4) full factorial design was employed to achieve the critical quality attributes of minimized par...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.12.069

    authors： Girotra P,Singh SK,Kumar G

    更新日期：2016-04-01 00:00:00

  • Evaluation of microwave assisted grafted sago starch as controlled release polymeric carrier.

    abstract：:In the present investigation an attempt has been made to develop a new co-polymeric material for controlled release tablet formulations. The acrylamide grafting was successfully performed on the backbone of sago starch. The modified starch was tested for acute toxicity and drug-excipient compatibility study. The graft...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.05.008

    authors： Singh AV,Nath LK

    更新日期：2013-09-01 00:00:00

  • Chitosan/Sterculia striata polysaccharides nanocomplex as a potential chloroquine drug release device.

    abstract：:Nanoparticles are produced by means of polyelectrolyte complexation (PEC) of oppositely charged polycationic chitosan (CH) with polyanionic polysaccharide extracted from Sterculia striata exudates (rhamnogalacturonoglycan (RG)-type polysaccharide). The nanoparticles formed with low-molar-mass CH are larger than those ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.03.070

    authors： Magalhães GA Jr,Moura Neto E,Sombra VG,Richter AR,Abreu CM,Feitosa JP,Paula HC,Goycoolea FM,de Paula RC

    更新日期：2016-07-01 00:00:00

  • Isolation and processing of silk proteins for biomedical applications.

    abstract：:Silk proteins of silkworms are chiefly composed of core fibroin protein and glycoprotein sericin that glues fibroin. Unique mechanical properties, cyto-compatibility and controllable biodegradability facilitate the use of fibroin in biomedical applications. Sericin serves as additive in cosmetic and food industries, a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.06.022

    authors： Kundu B,Kurland NE,Yadavalli VK,Kundu SC

    更新日期：2014-09-01 00:00:00

  • Selective adsorption of Pd (II) by ion-imprinted porous alginate beads: Experimental and density functional theory study.

    abstract：:In this study, a novel thiourea grafted porous sodium alginate-based adsorbent was synthesized by combining ion-imprinting and direct templating method. Due to ion-imprinting, the prepared adsorbent has demonstrated outstanding selectivity towards Pd (II) from bi-metallic solution at different pH values. Langmuir and ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.153

    authors： Gao X,Guo C,Hao J,Zhao Z,Long H,Li M

    更新日期：2020-08-15 00:00:00

  • Investigation of the physical properties, antioxidant and antimicrobial activity of ternary potato starch-furcellaran-gelatin films incorporated with lavender essential oil.

    abstract：:Lavender essential oil (OEL) was added to starch, furcellaran and gelatin (S/F/G) films in concentrations of 2%, 4% and 6%. The films were examined in terms of physical properties (thickness, density, water solubility, water absorption and degree of swelling) and mechanical properties (tensile strength, elongation at ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.04.014

    authors： Jamróz E,Juszczak L,Kucharek M

    更新日期：2018-07-15 00:00:00

  • Immobilization of rat brain acetylcholinesterase on porous gold-nanoparticle-CaCO₃ hybrid material modified Au electrode for detection of organophosphorous insecticides.

    abstract：:An acetylcholinesterase (AChE) purified from rat brain was immobilized onto gold nanoparticles (AuNPs) assembled on the surface of porous calcium carbonate (CaCO(3)) microsphere. The resulting AChE-AuNPs-CaCO(3) bioconjugate was mounted on the surface of Au electrode with the help of silica sol-gel matrix to prepare t...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.08.006

    authors： Chauhan N,Narang J,Pundir CS

    更新日期：2011-12-01 00:00:00

  • Biomaterials cross-linked graphene oxide composite aerogel with a macro-nanoporous network structure for efficient Cr (VI) removal.

    abstract：:Chitosan (CS) is an attractive bio-adsorbent in pollutant removal due to its environment-friendly properties and abundant adsorption sites. However, the weak mechanical properties and strong dissolubility in acidic conditions of CS hinder its wide application. Herein, a facile method was proposed to fabricate polydopa...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.174

    authors： Li L,Wei Z,Liu X,Yang Y,Deng C,Yu Z,Guo Z,Shi J,Zhu C,Guo W,Sun Z

    更新日期：2020-08-01 00:00:00