当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Sulfated polysaccharide from the green marine algae Caulerpa racemosa reduces experimental pain in the rat temporomandibular joint.

Sulfated polysaccharide from the green marine algae Caulerpa racemosa reduces experimental pain in the rat temporomandibular joint.

Abstract：

:Temporomandibular disorder is a clinical painful condition in the temporomandibular joint (TMJ) region. The purified sulfated polysaccharide from the green marine algae Caulerpa racemosa (Cr) has provided anti-inflammatory and antinociceptive activity. This study evaluated these effects on a TMJ hypernociception model. Wistar rats (180 - 250 g) were pre-treated (i.v.) with Cr at 0.01, 0.1, or 1 mg/kg or vehicle 30 min before formalin (1.5%/50 μL, i.art.), capsaicin (1.5%/20 μL, i.art.), or serotonin (225 μg/50 μL, i.art.) in the TMJ, and nociceptive behaviors were measured for 45 or 30 min upon inflammatory stimuli. Inflammatory parameters vascular permeability assay, TNF-α, and IL-1β by ELISA, protein expression of adhesion molecules ICAM-1 and CD55 by Western blot were assessed. The involvement of heme oxygenase-1 (HO-1) and nitric oxide (NO) pathways were assessed by pharmacological inhibition. Cr (1 mg/kg) reduced nociceptive behavior, plasmatic extravasation, TNF-α, and IL-1β levels, as well as ICAM-1 and CD55 expression in periarticular tissues. Cr antinociceptive effect was not prevented by aminoguanidine, but ZnPP-IX did reduce its antinociceptive effect. Therefore, Cr antinociceptive and anti-inflammatory effects in this experimental model of hypernociception depended on the HO-1 pathway integrity, as well as reducing peripheral inflammatory events, e.g., TNF-α and IL-1β cytokines levels, ICAM-1 and CD55 expression.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Ribeiro NA,Chaves HV,da Conceição Rivanor RL,do Val DR,de Assis EL,Silveira FD,Gomes FIF,Freitas HC,Vieira LV,da Silva Costa DV,de Castro Brito GA,Bezerra MM,Benevides NMB

doi

10.1016/j.ijbiomac.2020.01.272

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

253-260

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)39901-5

journal_volume

150

pub_type

杂志文章

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