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Structural characterization and in vitro biomedical activities of sulfated chitosan from Sepia pharaonis.

Abstract：

:A low molecular weight sulfated chitosan (SP-LMWSC) was isolated from the cuttlebone of Sepia pharaonis. Elemental analysis established the presence of C, H and N. The sulfation of SP-LMWSC was confirmed by the presence of characteristic peaks in FT-IR and FT-Raman spectra. The thermal properties of SP-LMWSC were studied by thermogravimetric analysis and differential scanning calorimetry. Electrolytic conductivity of SP-LMWSC was measured by cyclic voltammetry and the molecular weight was determined by MALDI-TOF/MS. The molecular structure and sulfation sites of SP-LMWSC were unambiguously confirmed using (1)H, (13)C, 2D COSY and 2D HSQC NMR spectroscopy. SP-LMWSC exhibited increased anticoagulant activity in avian blood by delaying coagulation parameters and displayed cytostatic activity by inhibiting the migration of avian leucocytes. SP-LMWSC demonstrated avian antiviral activity by binding to Newcastle disease virus receptors at a low titer value of 1/64. These findings suggested that SP-LMWSC isolated from an industrial discard holds immense potentials as carbohydrate based pharmaceuticals in future.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Karthik R,Manigandan V,Saravanan R,Rajesh RP,Chandrika B

doi

10.1016/j.ijbiomac.2015.12.030

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

319-28

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)30215-4

journal_volume

84

pub_type

杂志文章

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