Stabilization of collagen using plant polyphenol: role of catechin.

Abstract:

:Collagen, a unique connective tissue protein finds extensive application as biocompatible biomaterial in wound healing, as drug carriers, cosmetics, etc. A work has been undertaken to study the stabilization of type I collagen using the plant polyphenol catechin. Catechin treated collagen fibres showed a shrinkage temperature around 70 degrees C implying that catechin is able to impart thermal stability to collagen. Catechin treated collagen fibres has been found to be stable even after treatment with high concentration of the secondary structural destabilizer, urea. Circular dichroism studies revealed that there is no major alteration in the structure of collagen on treatment with catechin. The study has demonstrated the involvement of hydrogen bonding and hydrophobic interactions as the major forces involved in the stabilization of collagen by the plant polyphenol, catechin.

journal_name

Int J Biol Macromol

authors

Madhan B,Subramanian V,Rao JR,Nair BU,Ramasami T

doi

10.1016/j.ijbiomac.2005.08.005

keywords:

subject

Has Abstract

pub_date

2005-10-30 00:00:00

pages

47-53

issue

1-2

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(05)00178-9

journal_volume

37

pub_type

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