当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications.

Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications.

Abstract：

:The aim of this study was to fabricate a novel bilayer scaffold containing cellulose nanofiber/poly (vinyl) alcohol (CNF/PVA) to evaluate its potential use in skin tissue engineering. Here, the scaffolds were fabricated using a novel one-step freeze-drying technique with two different concentrations of the aforementioned polymers. FE-SEM analysis indicated that the fabricated scaffolds had interconnected pores with two defined pore size in each layer of the bilayer scaffolds that can recapitulate the two layers of the dermis and epidermis of the skin. Lower concentration of polymers causes higher porosity with larger pore size and increased water uptake and decreased mechanical strength. FTIR proved the presence of functional groups and strong hydrogen bonding between the molecules of CNF/PVA and the efficient crosslinking. The MTT assay showed that these nanofibrous scaffolds meet the requirement as a biocompatible material for skin repair. Here, for the first time, we fabricated bilayer scaffold using a novel one-step freeze-drying technique only by controlling the polymer concentration with spending less time and energy.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Ghafari R,Jonoobi M,Amirabad LM,Oksman K,Taheri AR

doi

10.1016/j.ijbiomac.2019.06.104

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

796-803

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)32333-5

journal_volume

136

pub_type

杂志文章

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