当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Carbon dot festooned and surface passivated graphene-reinforced chitosan construct for tumor-targeted delivery of TNF-α gene.

Carbon dot festooned and surface passivated graphene-reinforced chitosan construct for tumor-targeted delivery of TNF-α gene.

Abstract：

:Gene therapy is a promising alternative that ensures effective treatment and cure for cancer. Here, we report graphene-reinforced chitosan (CS) construct based non-viral vector for tumor-targeted gene therapy. The therapeutic gene, pDNA-TNF-α, was loaded on to chitosan-carboxylated graphene oxide (CS-CGO) construct via electrostatic interaction. The pDNA-TNF-α-CS-CGO thus obtained was further passivated with 4,7,10-trioxa-1,13-tridecanediamine for protecting the vector from the mononuclear phagocyte system that contributes to the prolongation of circulation half-life. The surface passivated carrier (PEG-pDNA-TNF-α-CS-CGO) then festooned with the folic acid derived carbon dots (C-dots) for targeting folate receptors that are overexpressed in most of the cancer cells. The results of TEM images and zeta potential values ensured the occurrence of desired changes in each stage of C-dot-PEG-pDNA-TNF-α-CS-CGO formulation. After 14 days of incubation, the anti-angiogenesis effect was observed for final formulation in the chorioallantoic membrane. The results of in vitro gene expression study in cancer cell line show a comparatively higher transfection efficacy of the developed system (C-dot-PEG-pDNA-TNF-α-CS-CGO) than pDNA-TNF-α. The efficiency of the developed gene delivery system was further confirmed using a developed and validated artificial tumor cell apparatus.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Jaleel JA,Ashraf SM,Rathinasamy K,Pramod K

doi

10.1016/j.ijbiomac.2019.01.174

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

628-636

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)35300-5

journal_volume

127

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Selective adsorption of Pd (II) by ion-imprinted porous alginate beads: Experimental and density functional theory study.

    abstract：:In this study, a novel thiourea grafted porous sodium alginate-based adsorbent was synthesized by combining ion-imprinting and direct templating method. Due to ion-imprinting, the prepared adsorbent has demonstrated outstanding selectivity towards Pd (II) from bi-metallic solution at different pH values. Langmuir and ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.153

    authors： Gao X,Guo C,Hao J,Zhao Z,Long H,Li M

    更新日期：2020-08-15 00:00:00

  • Preparation and characterization of pH-responsive guar gum microspheres.

    abstract：:Guar gum, being the natural polymer is renewable, nontoxic, biocompatible and biodegradable. Therefore, it is the perfect material to formulate particulates or microspheres for potential applications in pharmaceutical. The formulation of material in nano/microsphere scale offers new rich in application potential. In v...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.09.045

    authors： Sharma S,Kaur J,Sharma G,Thakur KK,Chauhan GS,Chauhan K

    更新日期：2013-11-01 00:00:00

  • UV-mediated solid-state cross-linking of electrospinning nanofibers of modified collagen.

    abstract：:The modified collagen with double bonds was electrospun into nanofibers membrane cured with photo-initiated polymerization under UV irradiation. The morphology and chemical structures were characterized by SEM and FTIR. Both the water resistance and mechanical properties were improved after UV-crosslinking. Then 5-Flu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.029

    authors： Song X,Dong P,Gravesande J,Cheng B,Xing J

    更新日期：2018-12-01 00:00:00

  • Isolation and further structural characterization of lignins from the valonea of Quercus variabilis.

    abstract：:The isolation process of alkali lignin (AL) from the valonea of Quercus variabilis Blume was optimized (liquid/solid ratio, 12.21; isolation time, 4.21h; isolation temperature, 42.21°C; and alkali concentration, 0.85mol/L) using the response surface method (RSM), with the highest isolation rate obtained being 22.67%. ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.01.008

    authors： Yang L,Wang D,Zhou D,Zhang Y,Yang T

    更新日期：2017-04-01 00:00:00

  • The first characterization of a cystatin and a cathepsin L-like peptidase from Aedes aegypti and their possible role in DENV infection by the modulation of apoptosis.

    abstract：:Recently, a salivary gland transcriptome study demonstrated that the transcripts of a putative cystatin gene (SeqID AAEL013287; Aacystatins) from Aedes aegypti were increased in DENV2-infected mosquitoes and that silencing of the Aacystatin gene resulted in an increase in DENV titres. In this work, Aacystatin was bioc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.010

    authors： Oliveira FAA,Buri MV,Rodriguez BL,Costa-da-Silva AL,Araújo HRC,Capurro ML,Lu S,Tanaka AS

    更新日期：2020-03-01 00:00:00

  • Chitosan and carboxymethyl cellulose based magnetic nanocomposites for application of peroxidase purification.

    abstract：:Recently, protein purification methods have a very wide area of research. Many of these methods are both expensive and multi-stage methods, that are needed in specific equipment. In this study, biopolymer coated magnetic nanoparticles, carboxymethyl cellulose (CMC) and chitosan (CH) coated Fe3O4 (magnetite) nanocompos...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.12.042

    authors： Zengin Kurt B,Uckaya F,Durmus Z

    更新日期：2017-03-01 00:00:00

  • Crystal structure of CntK, the cofactor-independent histidine racemase in staphylopine-mediated metal acquisition of Staphylococcus aureus.

    abstract：:Staphylopine is a newly identified broad-spectrum metallophore for metal acquisition, and it plays important roles in the survival and virulence of Staphylococcus aureus and other pathogens in the metal-scarce environment in hosts. CntK catalyzes the first step of staphylopine synthesis by converting L-histidine to D-...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.05.169

    authors： Luo S,Ju Y,Zhou J,Gu Q,Xu J,Zhou H

    更新日期：2019-08-15 00:00:00

  • Lunatin, a novel lectin with antifungal and antiproliferative bioactivities from Phaseolus lunatus billb.

    abstract：:A novel lectin with a molecular mass of 24.3kDa, designated Lunatin, was isolated from edible seeds of Phaseolus lunatus billb. The purification scheme consisted of ammonium sulfate precipitation, affinity chromatography, ion exchange chromatography, and gel filtration chromatography. The lectin is a glycoprotein, as ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.04.092

    authors： Wu J,Wang J,Wang S,Rao P

    更新日期：2016-08-01 00:00:00

  • The attenuation of HIV-1 Tat-induced neurotoxicity by Salvianic acid A and Danshen granule.

    abstract：:The neurotoxicity of HIV-1 Tat protein contributes significantly to the pathogenesis of HAND, and hence the attractive therapeutic strategies focusing on Tat-induced neurotoxicity are warranted. Salvia miltiorrhiza have been known to antioxidant property and neuroprotective effects. The Danshen granule is the pharmace...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.146

    authors： Bao D,Wang J,Liu J,Qin T,Liu H

    更新日期：2019-03-01 00:00:00

  • Purification and structural characterization of a novel antioxidant and antibacterial protein from Arca inflata.

    abstract：:A novel protein (J2-C4) with antioxidant and antibacterial activities was purified from the edible portion of Arca inflata. The purity of J2-C4 was measured to be 97.62% by RP-HPLC analysis, and the molecular weight was 20,537.0 Da by ESI-MS/MS. The isoelectric point of J2-C4 was determined to be 5.18 by IEF-PAGE. Sec...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.008

    authors： Wang W,Shi H,Zhu J,Li C,Song L,Yu R

    更新日期：2018-09-01 00:00:00

  • Starch based biodegradable graft copolymer for the preparation of silver nanoparticles.

    abstract：:The synthesis and characterization of a novel biodegradable graft copolymer based on partially hydrolyzed polymethylacrylate (PMA) grafted amylopectin (AP) was reported which was developed for the synthesis of silver nanoparticles from silver nitrate solution by facile green technique. The prepared graft copolymer was...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.07.046

    authors： Das S,Sasmal D,Pal S,Kolya H,Pandey A,Tripathy T

    更新日期：2015-11-01 00:00:00

  • Synthesis, characterization and cytocompatibility studies of α-chitin hydrogel/nano hydroxyapatite composite scaffolds.

    abstract：:α-chitin hydrogel/nano hydroxyapatite (nHAp) composite scaffold have been synthesized by freeze-drying approach with nHAp and α-chitin hydrogel. The prepared nHAp and nanocomposite scaffolds were characterized using DLS, SEM, FT-IR, XRD and TGA studies. The porosity, swelling, degradation, protein adsorption and biomi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.03.006

    authors： Kumar PT,Srinivasan S,Lakshmanan VK,Tamura H,Nair SV,Jayakumar R

    更新日期：2011-07-01 00:00:00

  • TPR domain of Ser/Thr phosphatase of Aspergillus oryzae shows no auto-inhibitory effect on the dephosphorylation activity.

    abstract：:A Ser/Thr phosphatase gene cloned from Aspergillus oryzae, aoppt, revealed that the tetratricopeptide repeat (TPR) and catalytic domains of the full-length AoPPT are located at the N- and C-terminal regions, respectively, similar to those of human Ser/Thr phosphatase 5 (PP5) and yeast Ppt1. Four different regions of A...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.03.005

    authors： Feng B,Zhao CH,Tanaka S,Imanaka H,Imamura K,Nakanishi K

    更新日期：2007-08-01 00:00:00

  • Secretory expression, characterization and docking study of glucose-tolerant β-glucosidase from B. subtilis.

    abstract：:The thermostable, glucose tolerant β-glucosidase gene (bgl) of Glycoside hydrolase family 1, isolated from Bacillus subtilis, was cloned and overexpressed in Escherichia coli. The bgl has open reading frame of 1,407 bp, encoding 469 amino acids with predicted molecular weight of 53 kDa. The recombinant protein (BGL) w...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.01.001

    authors： Chamoli S,Kumar P,Navani NK,Verma AK

    更新日期：2016-04-01 00:00:00

  • Particles of liquid-crystalline dispersions formed by (nucleic acid-rare earth element) complexes as a potential platform for neutron capture therapy.

    abstract：:Microscopic size particles of the cholesteric double-stranded DNA (RNA) liquid-crystalline dispersions, containing the ions of the rare earth elements in their content, have been obtained for the first time. The properties of these particles differ from those of classical DNA cholesterics noticeably. The local concent...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.10.001

    authors： Yevdokimov YM,Salyanov VI,Kondrashina OV,Borshevsky VI,Semenov SV,Gasanov AA,Reshetov IV,Kuznetsov VD,Nikiforov VN,Akulinichev SV,Mordovskoi MV,Potashev SI,Skorkin VM

    更新日期：2005-12-15 00:00:00

  • Valorization of industrial xylan-rich hemicelluloses into water-soluble derivatives by in-situ acetylation in EmimAc ionic liquid.

    abstract：:In this study, aimed at valorization of industrial xylan-rich hemicelluloses (a by-product of dissolving pulp process), water-soluble hemicelluloses were fabricated with mild acetylation in 1-ethyl-3-methylimidazolium acetate ionic liquid (EmimAc) and dichloroacetyl chloride (Cl2AcCl) system by a facile and novel meth...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.289

    authors： Zhu R,Liu X,Li L,Wang Q,Zhao Q,Liu S,Feng W,Xu F,Zhang X

    更新日期：2020-11-15 00:00:00

  • Size controllable one step synthesis of gold nanoparticles using carboxymethyl chitosan.

    abstract：:Gold nanoparticles (AuNPs) were synthesized by reducing chloroauric acid with nontoxic and biodegradable carboxymethyl chitosan (CMC) as dual roles of reducing agent and stabilizer. Several CMC with different molecular parameters, i.e., degree of substitution (DS), substitution position, degree of deacetylation (DD) a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.006

    authors： Sun L,Pu S,Li J,Cai J,Zhou B,Ren G,Ma Q,Zhong L

    更新日期：2019-02-01 00:00:00

  • Synthesis and conformational analysis of Aib-containing peptide modelling for N-glycosylation site in N-glycoprotein.

    abstract：:A tetrapetide containing an Aib residue, Boc-Asn-Aib-Thr-Aib-OMe, was synthesized as a peptide model for the N-glycosylation site in N-glycoproteins. Backbone conformation of the peptide and possible intramolecular interaction between the Asn and Thr side chains were elucidated by means of n.m.r. spectroscopy. Tempera...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(89)90003-2

    authors： Ishii H,Nadaoka O,Mimura Y,Inoue Y,Chûjô R

    更新日期：1989-12-01 00:00:00

  • Protective effects of sulfated chitooligosaccharides with different degrees of substitution in MIN6 cells.

    abstract：:Chitosan, a naturally occurring biopolymer, has received considerable attention for pharmaceutical applications due to its biocompatible, biodegradable and less toxic properties. In this study, sulfated chitooligosaccharides (COS-S) with different degrees of substitution (DS) were prepared to improve both its water-so...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.09.032

    authors： Lu X,Guo H,Sun L,Zhang L,Zhang Y

    更新日期：2013-01-01 00:00:00

  • The protective effects of walnut green husk polysaccharide on liver injury, vascular endothelial dysfunction and disorder of gut microbiota in high fructose-induced mice.

    abstract：:This study aimed to investigate the protective effects of walnut green husk polysaccharide (WGHP) on liver injury, vascular endothelial dysfunction and disorder of gut microbiota in mice induced by high fructose (HF) diet. The chemical analysis results show that the walnut green husk polysaccharide is a low molecular ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.055

    authors： Wang G,Zhang Y,Zhang R,Pan J,Qi D,Wang J,Yang X

    更新日期：2020-11-01 00:00:00

  • Substrate-imprinted docking of Agrobacterium tumefaciens uronate dehydrogenase for increased substrate selectivity.

    abstract：:Agrobacterium tumefaciens uronate dehydrogenase (AtuUdh) belongs to the short-chain dehydrogenase superfamily, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. It is apparently required for the production of D-glucaric acid. AtuUdh-catalyzed reaction is reversible with dual substra...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.194

    authors： Murugan A,Prathiviraj R,Mothay D,Chellapandi P

    更新日期：2019-11-01 00:00:00

  • Encapsulation of probiotic Bifidobacterium longum BIOMA 5920 with alginate-human-like collagen and evaluation of survival in simulated gastrointestinal conditions.

    abstract：:Alginate (ALg)-human-like collagen (HLC) microspheres were prepared by the technology of electrostatic droplet generation in order to develop a biocompatible vehicle for probiotic bacteria. Microparticles were spherical with mean particle size of 400μm. The encapsulation efficiency (EE) of ALg-HLC microspheres could r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.08.018

    authors： Su R,Zhu XL,Fan DD,Mi Y,Yang CY,Jia X

    更新日期：2011-12-01 00:00:00

  • Effect of a modified thymine on the structure and stability of [d(TGGGT)]4 quadruplex.

    abstract：:Telomeric guanine-rich sequence can adopt quadruplex structures that are important for their biological role in chromosomal stabilisation. G quartets are characterised by the cyclic hydrogen bonding of four guanine bases in a coplanar arrangement and their stability is ion-dependent. In this work we compare the stabil...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00073-9

    authors： Petraccone L,Erra E,Nasti L,Galeone A,Randazzo A,Mayol L,Barone G,Giancola C

    更新日期：2003-01-15 00:00:00

  • Glu residues of βDELSEED-motif are essential for peptide binding in Escherichia coli ATP synthase.

    abstract：:The current study establishes the necessity of Glu-381, Glu-384, and Glu-385 in the βDELSEED-motif of Escherichia coli ATP synthase for peptide binding and inhibition. Inhibitory profiles of wild type and mutant E. coli membrane bound F1Fo ATP synthase were studied in the presence and absence of C-terminal NH2 bound m...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.118

    authors： Azim S,Ahmad Z

    更新日期：2018-09-01 00:00:00

  • Preparation and characterization of broken-rice starch nanoparticles with different sizes.

    abstract：:Broken-rice starch nanoparticles with different mean particle diameters for 100, 200, 400 and 800 nm were prepared by nanoprecipitation, alkali freezing, cross-linking and H2SO4 hydrolysis methods respectively, and their structural, morphological and physicochemical properties were systematically characterized. The re...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.182

    authors： Xiao H,Yang F,Lin Q,Zhang Q,Zhang L,Sun S,Han W,Liu GQ

    更新日期：2020-10-01 00:00:00

  • Polysaccharides from loquat (Eriobotrya japonica) leaves: Impacts of extraction methods on their physicochemical characteristics and biological activities.

    abstract：:Impacts of hot water extraction (HWE), pressurized water extraction (PWE), high-speed shearing homogenization extraction, microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), ultrasound assisted enzymatic extraction, and ultrasound-microwave assisted extraction (UMAE) on physicochemical character...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.273

    authors： Fu Y,Li F,Ding Y,Li HY,Xiang XR,Ye Q,Zhang J,Zhao L,Qin W,Gan RY,Wu DT

    更新日期：2020-03-01 00:00:00

  • In situ preparation of glycoconjugate hollow microspheres mimics the extracellular matrix via interfacial polymerization.

    abstract：:A novel chitin-graft-polyleucine microsphere with hollow construction was prepared via ring-opening polymerization initiated with chitin based on interfacial protocol. The FT-IR and (1)H NMR analysis demonstrated the conjugation with regulated graft length. The study provided a facile one-step route to obtain microsph...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2008.02.007

    authors： Wang J,Liu C,Chi P

    更新日期：2008-06-01 00:00:00

  • Influence of the ionic liquid 1-butyl-3-methylimidazolium bromide on amyloid fibrillogenesis in lysozyme: Evidence from photophysical and imaging studies.

    abstract：:Many proteins can abnormally fold to form pathological amyloid deposits/aggregates that are responsible for various degenerative disorders called amyloidosis. Here we have examined the anti-amyloidogenic potency of an ionic liquid, 1-butyl-3-methylimidazolium bromide, using lysozyme as a model system. Thioflavin T flu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.152

    authors： Basu A,Bhattacharya SC,Kumar GS

    更新日期：2018-02-01 00:00:00

  • Aspergillus oryzae S2 alpha-amylase production under solid state fermentation: optimization of culture conditions.

    abstract：:Aspergillus oryzae S2 was assayed for alpha-amylase production under solid state fermentation (SSF). In addition to AmyA and AmyB already produced in monitored submerged culture, the strain was noted to produce new AmyB oligomeric forms, in particular a dominant tetrameric form named AmyC. The latter was purified to h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.01.026

    authors： Sahnoun M,Kriaa M,Elgharbi F,Ayadi DZ,Bejar S,Kammoun R

    更新日期：2015-04-01 00:00:00

  • Solubility and rheological behavior of silk fibroin (Bombyx mori) in N-methyl morpholine N-oxide.

    abstract：:As an important direct solvent for cellulose, N-methyl morpholine N-oxide (NMMO) is environmentally friendly, and potentially very economical. Silk fibroin (SF) (Bombyx mori) can also be dissolved directly in NMMO.H2O. However, it is unexpectedly difficult to obtain a silk fibroin solution with a concentration higher ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2004.11.008

    authors： Xu Y,Zhang Y,Shao H,Hu X

    更新日期：2005-04-01 00:00:00