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UV-mediated solid-state cross-linking of electrospinning nanofibers of modified collagen.

Abstract：

:The modified collagen with double bonds was electrospun into nanofibers membrane cured with photo-initiated polymerization under UV irradiation. The morphology and chemical structures were characterized by SEM and FTIR. Both the water resistance and mechanical properties were improved after UV-crosslinking. Then 5-Fluorouracil (5-FU) was used as a model drug to prepare drug-loaded collagen nanofiber membrane cured with photo-initiated polymerization under UV irradiation. In vitro release results showed that drug release could be effectively controlled through UV-crosslinking. Furthermore, the release mechanism of drugs from electrospun mats was confirmed to be Fickian diffusion.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Song X,Dong P,Gravesande J,Cheng B,Xing J

doi

10.1016/j.ijbiomac.2018.09.029

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

2086-2093

issue

Pt B

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)33022-8

journal_volume

120

pub_type

杂志文章

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