当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Effect of a modified thymine on the structure and stability of [d(TGGGT)]4 quadruplex.

Effect of a modified thymine on the structure and stability of [d(TGGGT)]4 quadruplex.

Abstract：

:Telomeric guanine-rich sequence can adopt quadruplex structures that are important for their biological role in chromosomal stabilisation. G quartets are characterised by the cyclic hydrogen bonding of four guanine bases in a coplanar arrangement and their stability is ion-dependent. In this work we compare the stability of [d(TGGGT)](4) and [d(T*GGGT)](4) quadruplexes. The last one contains a modified thymine, where the hydroxyl group substitutes one hydrogen atom of the methyl group of the thymine in the [d(TGGGT)](4) sequence. We used a combination of spectroscopic, calorimetric and computational techniques to characterise the G-quadruplex formation. NMR and CD spectra of [d(T*GGGT)](4) were characteristic of parallel-stranded, tetramolecular quadruplex. CD and DSC melting experiments reveal that [d(T*GGGT)](4) is less stable that unmodified quadruplex. Molecular models suggest possible explanation for the observed behaviour.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Petraccone L,Erra E,Nasti L,Galeone A,Randazzo A,Mayol L,Barone G,Giancola C

doi

10.1016/s0141-8130(02)00073-9

keywords:

subject

Has Abstract

pub_date

2003-01-15 00:00:00

pages

131-7

issue

4-5

eissn

0141-8130

issn

1879-0003

pii

S0141813002000739

journal_volume

31

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Bufadienolides from Kalanchoe daigremontiana modulate the enzymatic activity of plasmin - In vitro and in silico analyses.

    abstract：:Plasmin (EC 3.4.21.7) is a key enzyme of the fibrinolytic system, responsible for the degradation of fibrin clot and maintaining blood fluidity. Hence, alterations of the fibrinolytic capacity of blood plasma may contribute to thrombotic or bleeding complications. The aim of this study was to determine effects of a bu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.143

    authors： Kolodziejczyk-Czepas J,Pasiński B,Ponczek MB,Moniuszko-Szajwaj B,Kowalczyk M,Pecio Ł,Nowak P,Stochmal A

    更新日期：2018-12-01 00:00:00

  • Exploring the interaction of anti-androgen drug-bicalutamide with human alpha-2-macroglobulin: A biophysical investigation.

    abstract：:Bicalutamide (BCT), a drug used in the treatment of prostate cancer, antagonises the actions of androgens, at the receptor level, thereby inhibiting the growth of prostate tumours. Alpha-2-macroglobulin (α2M), a pan-proteinase inhibitor, inhibits proteinase, regardless of specificity and catalytic mechanism. α2M is de...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.117

    authors： Zia MK,Siddiqui T,Ali SS,Ahsan H,Khan FH

    更新日期：2018-12-01 00:00:00

  • Biosynthesis and characterization of polyhydroxyalkanoates by Pseudomonas guezennei from alkanoates and glucose.

    abstract：:The biosynthesis of medium chain length poly(3-hydroxyalkanoates) mcl PHAs by Pseudomonas guezennei using glucose, sodium octanoate, and 10-undecenoic acid as sole or mixed carbon sources was investigated. Chemical composition of polyesters was analyzed by GCMS and NMR. The copolyester produced by P. guezennei from gl...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.08.018

    authors： Simon-Colin C,Gouin C,Lemechko P,Schmitt S,Senant A,Kervarec N,Guezennec J

    更新日期：2012-12-01 00:00:00

  • Synthesis, antimicrobial activity, and sustainable release of novel α-aminophosphonate derivatives loaded carrageenan cryogel.

    abstract：:Novel α-aminophosphonates 4 were synthesized via one pot three-component reaction of 4-aminoantipyrine, aldehydes, triphenylphosphite and Lewis acid catalyst. The chemical structures of all the synthesized compounds were elucidated by IR, NMR and MS spectral analysis. The antimicrobial activity of 4 was tested in vitr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.251

    authors： Elsherbiny DA,Abdelgawad AM,El-Naggar ME,El-Sherbiny RA,El-Rafie MH,El-Sayed IE

    更新日期：2020-11-15 00:00:00

  • Pulse release of doxazosin from hydroxyethylcellulose compression coated tablet: mechanistic and in vivo study.

    abstract：:Chronotherapeutically programmed hydroxyethylcellulose (HEC) based compression coated doxazosin tablets were prepared and the influence of disintegrants croscarmellose sodium, L-hydroxypropylcellulose (L-HPC), gellan gum on drug release and in vivo performance were investigated. Infrared spectroscopy and differential ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.08.028

    authors： Biswas N,Guha A,Sahoo RK,Kuotsu K

    更新日期：2015-01-01 00:00:00

  • Immobilization of rat brain acetylcholinesterase on porous gold-nanoparticle-CaCO₃ hybrid material modified Au electrode for detection of organophosphorous insecticides.

    abstract：:An acetylcholinesterase (AChE) purified from rat brain was immobilized onto gold nanoparticles (AuNPs) assembled on the surface of porous calcium carbonate (CaCO(3)) microsphere. The resulting AChE-AuNPs-CaCO(3) bioconjugate was mounted on the surface of Au electrode with the help of silica sol-gel matrix to prepare t...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.08.006

    authors： Chauhan N,Narang J,Pundir CS

    更新日期：2011-12-01 00:00:00

  • Aspergillus niger lectin elicits MyD88 dependent proliferation and apoptosis at lower and higher doses in immortalized human corneal epithelial cells leading to pathogenesis.

    abstract：:An L-fucose lectin, ANL from the corneal smears of a mycotic keratitis patient was reported earlier. Interaction of ANL with immortalized Human Corneal Epithelial Cells (HCECs) was studied in order to assign the role of ANL in pathogenesis. ANL showed strong binding to HCECs which could be blocked by L-fucose and muci...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.10.020

    authors： Jagadeesh N,Belur S,Chachadi VB,Roy S,Inamdar SR

    更新日期：2020-12-15 00:00:00

  • Experimental and theoretical study of IBC domain from human IP3R2; molecular cloning, bacterial expression and protein purification.

    abstract：:IP3 is a ubiquitous second messenger in eukaryotic cells that triggers Ca2+-release from intracellular stores. IP3 binds to intracellular IP3-receptor (IP3R) and induces conformational change within the ligand-binding domain which regulates Ca2+-release; hence, both IP3 and IP3R are key components of the signal transd...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.09.117

    authors： Amroudie MN,Ataei F

    更新日期：2019-03-01 00:00:00

  • Alzheimer's disease-associated ubiquitin mutant Ubb+1: Properties of the carboxy-terminal domain and its influence on biomolecular interactions.

    abstract：:Ubb+1, a ubiquitin (Ub) mutant protein originating from misreading of the Ub B gene, is found accumulated in brain tissues of Alzheimer's disease patients. The mutant attracts strong interest due to its possible participation in the molecular events leading to neurodegeneration. Ubb+1 is composed of the globular domai...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.11.121

    authors： Munari F,Bortot A,Assfalg M,D'Onofrio M

    更新日期：2018-03-01 00:00:00

  • Bioconversion of crude glycerol to polyhydroxyalkanoate by Bacillus thuringiensis under non-limiting nitrogen conditions.

    abstract：:Glycerol has emerged as a cheap waste material due to blooming biodiesel manufacturing units worldwide. The need is to exploit the crude glycerol (CG) to produce useful products such as polyhydroxyalkanoate (PHA). Bacillus thuringiensis EGU45 was found to produce 1.5-3.5 gP HA L(-1) from feed containing 1-10% CG (vv(-...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.03.046

    authors： Kumar P,Ray S,Patel SK,Lee JK,Kalia VC

    更新日期：2015-01-01 00:00:00

  • Effects of growth condition on the structure of glycogen produced in cyanobacterium Synechocystis sp. PCC6803.

    abstract：:Growth and glycogen production were characterized for Synechocystis sp. strain PCC6803 grown under continuous fluorescent light in four variations of BG-11 medium: either with (G+) or without (G-) 5mM glucose, and with a normal (N+, 1.5 g sodium nitrate/L) or a reduced (N-, 0.084 g sodium nitrate/L) nitrogen concentra...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2006.11.009

    authors： Yoo SH,Keppel C,Spalding M,Jane JL

    更新日期：2007-04-10 00:00:00

  • Physicochemical stability of curcumin emulsions stabilized by Ulva fasciata polysaccharide under different metallic ions.

    abstract：:The aim of this research was to investigate the effect of metallic ions (Na+, Ca2+, K+ and Mg2+) on the physicochemical stability of curcumin emulsions stabilized by Ulva fasciata polysaccharide (UFP). Mean droplet diameter, PdI, zeta-potential, microscopic morphology, and rheological properties of curcumin emulsion s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.07.018

    authors： Shao P,Qiu Q,Chen H,Zhu J,Sun P

    更新日期：2017-12-01 00:00:00

  • Binding of bivalent cations by xanthan in aqueous solution.

    abstract：:The interaction between xanthan and selected bivalent cations (Ca2+, Mg2+, Mn2+, Fe2+, Cu2+, Zn2+, Cd2+ and Pb2+) was studied by means of conductometry, viscometry, and nuclear magnetic resonance spectroscopy. Xanthan from Xanthomonas campestris was studied in comparison with dextran from Leuconostoc mesenteroides. Wh...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2008.06.001

    authors： Bergmann D,Furth G,Mayer C

    更新日期：2008-10-01 00:00:00

  • l-3,4-Dihydroxyphenylalanine templated anisotropic gold nano/micro-roses as potential disrupters/inhibitors of α-crystallin protein and its gleaned model peptide aggregates.

    abstract：:Cataract, the major cause of blindness worldwide occurs due to the misfolding and aggregation of the protein crystallin, which constitute a major portion of the lens protein. Other than the whole protein crystallin, the peptide sequences generated from crystallin as a result of covalent protein damage have also been s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.112

    authors： Kour A,Sharma S,Dube T,Bisht A,Sharma M,Mishra J,Ali ME,Panda JJ

    更新日期：2020-11-15 00:00:00

  • Preparation screening, production optimization and characterization of exopolysaccharides produced by Lactobacillus sanfranciscensis Ls-1001 isolated from Chinese traditional sourdough.

    abstract：:The present study focused on preparation screening, production optimization and characterization of exopolysaccharides (EPS) produced by Lactobacillus sanfranciscensis isolated from a Chinese traditional sourdough sample. In addition, in vitro antioxidant activity of pure EPS was determined. A total of 51 strains of L...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.077

    authors： Zhang G,Zhang W,Sun L,Sadiq FA,Yang Y,Gao J,Sang Y

    更新日期：2019-10-15 00:00:00

  • Structure function relationships of transgenic starches with engineered phosphate substitution and starch branching.

    abstract：:Potato tuber starch was genetically engineered in the plant by the simultaneous antisense suppression of the starch branching enzyme (SBE) I and II isoforms. Starch prepared from 12 independent lines and three control lines were characterised with respect to structural and physical properties. The lengths of the amylo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.05.006

    authors： Blennow A,Wischmann B,Houborg K,Ahmt T,Jørgensen K,Engelsen SB,Bandsholm O,Poulsen P

    更新日期：2005-08-01 00:00:00

  • Diagnosing human blood clotting deficiency.

    abstract：:There are different clotting factors present in blood, carries the clotting cascade and excessive bleeding may cause a deficiency in the clotting Diagnosis of this deficiency in clotting drastically reduces the potential fatality. For enabling a sensor to detect the clotting factors, suitable probes such as antibody a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2018.05.084

    authors： Ong CC,Gopinath SCB,Rebecca LWX,Perumal V,Lakshmipriya T,Saheed MSM

    更新日期：2018-09-01 00:00:00

  • Recognition of active and inactive catalytic triads: A template based approach.

    abstract：:It is well established that a sequence template along with the database is a powerful tool for identifying the biological function of proteins. Here, we describe a method for predicting the catalytic nature of certain proteins among the several protein structures deposited in the Protein Data Bank (PDB). For the prese...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.01.011

    authors： Gupta V,Prakash NA,Lakshmi V,Boopathy R,Jeyakanthan J,Velmurugan D,Sekar K

    更新日期：2010-04-01 00:00:00

  • Vigilin interacts with CTCF and is involved in the maintenance of imprinting of IGF2 through a novel RNA-mediated mechanism.

    abstract：:Accumulating evidence has revealed the imprinting of insulin-like growth factor-2 gene (IGF2) is maintained by binding of CCCTC binding factor (CTCF) to the unmethylated imprinting control region (ICR) between IGF2 and H19 genes. We have previously reported that high-density lipoprotein binding protein (HDLBP/vigilin)...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.11.109

    authors： Yu X,Liu Q,He J,Huang Y,Jiang L,Xie X,Liu J,Chen L,Wei L,Qin Y

    更新日期：2018-03-01 00:00:00

  • Effect of increased PHA synthase activity on polyhydroxyalkanoates biosynthesis in Synechocystis sp. PCC6803.

    abstract：:Polyhydroxyalkanoate (PHA) synthase activity in Synechocystis sp. PCC6803 was increased two-fold by introducing the PHA biosynthetic genes of Ralstonia eutropha. The resulting recombinant Synechocystis sp. PCC6803 strain was subjected to conditions that favor PHA accumulation and the effects of various carbon sources ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00010-7

    authors： Sudesh K,Taguchi K,Doi Y

    更新日期：2002-04-08 00:00:00

  • Preparation, physical-chemical and biological characterization of chitosan nanoparticles loaded with lysozyme.

    abstract：:A commercially available chitosan (CS) was employed in the formulation of nanoparticles loaded with lysozyme (LZ) as antimicrobial protein drug model. Due to the variability of commercially available batches of chitosans and to the strict dependence of their physical and biological properties to the molecular weight (...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.03.016

    authors： Piras AM,Maisetta G,Sandreschi S,Esin S,Gazzarri M,Batoni G,Chiellini F

    更新日期：2014-06-01 00:00:00

  • Some biophysical applications of motional contrast in n.m.r. microscopy.

    abstract：:The principal advantage of the n.m.r. imaging method lies in the specific contrasts which are available. In this work we describe the use of velocity and diffusion contrast methods in biophysical applications and at microscopic spatial resolution. In the first example, involving water-protein interactions, the relatio...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(91)90045-v

    authors： Back PJ,Coy A,Xia Y,Callaghan PT,Diamante LM,Umbach SL

    更新日期：1991-06-01 00:00:00

  • Engineering a chimeric acid-stable α-amylase-glucoamylase (Amy-Glu) for one step starch saccharification.

    abstract：:For saccharifying starch in one step, a chimeric biocatalyst (Amy-Glu) was generated from engineered α-amylase (Ba-Gt-amy) of Bacillus acidicola and glucoamylase (Glu) gene of Aspergillus niger. In order to join two enzymes, a linker peptide of 25 amino acids was used. Chimeric Amy-Glu was expressed in E. coli. Glu is...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.02.083

    authors： Parashar D,Satyanarayana T

    更新日期：2017-06-01 00:00:00

  • Impact of lysyl oxidase (G473A) polymorphism on diabetic foot ulcers.

    abstract：:Lysyl oxidase (LOX) is an extra-cellular matrix-modifying enzyme that has been linked to cell proliferation, metastasis, angiogenesis and wound healing. This study was designed to examine the association of LOX gene polymorphism G473A, G>A, (rs1800449) located in exon 1 of the LOX gene in diabetic subjects with and wi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.05.050

    authors： Pichu S,Sathiyamoorthy J,Vimalraj S,Viswanathan V,Chatterjee S

    更新日期：2017-10-01 00:00:00

  • Active edible films of methylcellulose with extracts of green apple (Granny Smith) skin.

    abstract：:The aim a present study was developed methylcellulose (MC) active edible films with extracts of green apple skin, as model systems of edible coating. Active edible films were developed by incorporation of ethanolic extract of freeze-dried apple skin (EEFD) and aqueous extract of apple skin (AES) at 10, 20 and 25% (v/v...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.12.114

    authors： Matta E,Tavera-Quiroz MJ,Bertola N

    更新日期：2019-03-01 00:00:00

  • Comparative effects of limited tryptic hydrolysis on physicochemical and structural features of seed 11S globulins.

    abstract：:The effect of the limited proteolysis by trypsin on selected seed storage 11S globulins (broad bean and pea legumins, glycinin and helianthinin) was studied by high-sensitive differential scanning calorimetry, fluorescence spectroscopy and analysis of proteolysis kinetics. Different behaviour of glycinin and helianthi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.12.006

    authors： Braudo EE,Danilenko AN,Guslyannikov PV,Kozhevnikov GO,Artykova GP,Lapteva NA,Vaintraub IA,Sironi E,Duranti M

    更新日期：2006-11-15 00:00:00

  • It takes two to tango - The case of thebaine 6-O-demethylase.

    abstract：:Thebaine 6-O-demethylase (T6ODM) is an Fe(II)/2-oxoglutarate-dependent dioxygenase catalysing two oxidative O-demethylation reactions in morphine biosynthesis. Its crystal structure revealed a large active site pocket which is at least two times larger than necessary to accommodate a substrate (thebaine or oripavine) ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.030

    authors： Kachhap S,Wojdyla Z,Komorek P,Kluza A,Kurpiewska K,Jachimska B,Borowski T

    更新日期：2020-11-15 00:00:00

  • Composition and bioactivity of polysaccharides from Inula britannica flower.

    abstract：:In this paper, the composition and biological activities of polysaccharides from Inula britannica flower IBP obtained by water extraction were investigated. The properties and chemical compositions of IBP were analyzed with HPLC and IR methods. The results showed that IBP consisted of two kinds of polysaccharides with...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.06.021

    authors： Hong T,Zhao J,Dong M,Meng Y,Mu J,Yang Z

    更新日期：2012-11-01 00:00:00

  • Antitumor and immunomodulatory activity of polysaccharides from the root of Limonium sinense Kuntze.

    abstract：:Limonium sinense (Girard) Kuntze is a traditional Chinese folk medicine used for the treatment of fever, hemorrhage, hepatitis and other disorders. The study focused on the antitumor and immunomodulatory activities of L. sinense polysaccharides (LSP) which was obtained from the root of the plant. The antitumor effects...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.08.037

    authors： Tang XH,Yan LF,Gao J,Yang XL,Xu YX,Ge HY,Yang HD

    更新日期：2012-12-01 00:00:00

  • New crosslinked-chitosan graft poly(N-vinyl-2-pyrrolidone) for the removal of Cu(II) ions from aqueous solutions.

    abstract：:Crosslinked chitosan beads were grafted with N-vinyl-2-pyrrolidone (NVP) using ammonium persulfate (APS) as free radical initiator. Important variables on graft copolymerization such as temperature, reaction time, concentration of initiator and concentration of monomer were optimized. The results revealed optimum cond...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.09.061

    authors： Sutirman ZA,Sanagi MM,Abd Karim J,Abu Naim A,Wan Ibrahim WA

    更新日期：2018-02-01 00:00:00