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Protective effects of sulfated chitooligosaccharides with different degrees of substitution in MIN6 cells.

Abstract：

:Chitosan, a naturally occurring biopolymer, has received considerable attention for pharmaceutical applications due to its biocompatible, biodegradable and less toxic properties. In this study, sulfated chitooligosaccharides (COS-S) with different degrees of substitution (DS) were prepared to improve both its water-solubility and bioactivity. Additionally, the protective effects of COS-S on hydrogen peroxide (H(2)O(2))-induced dysfunction in MIN6 cells were investigated. COS-SI (DS, 0.8) and COS-SII (DS, 1.9) significantly increased the cell viability in a dose-dependent manner. COS-S also significantly suppressed NO production, the activity and mRNA expression of iNOS, and the protein level of NF-κB protein p65, which were activated by H(2)O(2). Furthermore, we demonstrated that COS-S led to an increase in the Bcl-2/Bax mRNA expression ratio and the inhibition of Caspase-3 mRNA expression in H(2)O(2)-stimulated MIN6 cells. Additionally, COS-SII (DS, 1.9) exhibited a superior protective effect on H(2)O(2)-induced apoptosis compared to COS-SI (DS, 0.8). These results indicated the good anti-oxidative capacity of COS-S and the possible mechanism via the blockade of the NF-κB signaling pathway. The protective effects of COS-S against oxidative injuries in MIN6 cells were depended on both DS and concentration.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Lu X,Guo H,Sun L,Zhang L,Zhang Y

doi

10.1016/j.ijbiomac.2012.09.032

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

92-8

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(12)00386-8

journal_volume

52

pub_type

杂志文章

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