Abstract:
:Sedum dendroideum is popularly known as balsam and used for treatment of inflammatory disorders. Two polysaccharides (RSBAL-H2O and RSBAL-0.5) were isolated from infusion of its dried leaves, using dialysis at 100kDa cut-off membrane and anion exchange chromatography. Methylation and NMR analyses showed that RSBAL-H2O is a highly methyl-esterified homogalacturonan, constituted by (1→4)-α-D-GalA residues, whereas RSBAL-0.5 is a highly methyl-esterified homogalacturonan branched at O-3, probably by type II arabinogalactans and arabinans. In this study we showed that these balsam polysaccharides stimulate secretion of the cytokines TNF-α, IL-1β and IL-10 by THP-1 macrophages, acting as immunostimulatory agents. But, on the other hand, they reduce TNF-α and IL1-β secretion induced by a pro-inflammatory agent (LPS), showing anti-inflammatory effect.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Oliveira AF,Nascimento GED,Iacomini M,Cordeiro LMC,Cipriani TRdoi
10.1016/j.ijbiomac.2017.07.122subject
Has Abstractpub_date
2017-12-01 00:00:00pages
940-946issue
Pt 1eissn
0141-8130issn
1879-0003pii
S0141-8130(17)31447-2journal_volume
105pub_type
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