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Interactions between flavonoids and hemoglobin in lecithin liposomes.

Abstract：

:In this paper, the binding of flavonoids (quercetin and rutin) to hemoglobin (Hb) have been investigated by fluorescence, absorption spectroscopy and circular dichroism (CD) spectroscopy. The binding parameters and binding mode between flavonoids and Hb are determined and the results of CD and synchronous fluorescence spectra indicate a conformational change of Hb with addition of flavonoids. The effects of lecithin liposomes on the binding parameter of quercetin and rutin to Hb are also studied. When incorporated into liposome, flavonoids can reduce the fluorescence of tryptophanyl residues of Hb to a lesser extent. The difference of the structure characteristics between quercetin and rutin has a significant effect on their binding affinity for Hb.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Xi J,Guo R

doi

10.1016/j.ijbiomac.2006.08.011

subject

Has Abstract

pub_date

2007-03-10 00:00:00

pages

305-11

issue

4

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(06)00249-2

journal_volume

40

pub_type

杂志文章

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