Abstract:
:Pectin has been regarded as a drug carrier accelerating the healing process due to its bioactivities, abundance and lower cost of resources. However, a big challenge related to its practical application is its poor mechanical strength. In this study the modified Cu-based MOF containing Folic acid was synthesized and incorporated in the suitable pectin electrospun nanofibers which not only improved the copper ions release behavior but also made the fiber mat stronger, antibacterial and induce angiogenesis, fibroblast migration, and proliferation due to loaded copper ions and folic acid. The nanofibers composing of 75% pectin and 4000 kDa -PEO were chosen after morphological and mechanical characterization. Finally, the effect of MOF incorporation on the nanocomposite samples was characterized in terms of morphological, physiochemical and biological properties. The nanofibrous mats were evaluated by tensile testing, antibacterial and cytotoxicity. The release behavior of copper ions and folic acid was controlled and their burst release alleviated reducing cytotoxicity in vitro. It was found that the Young's moduli of the pectin nanofibers were improved to 19.13 MPa by the addition of Cu-based MOFs. Moreover, nanocomposite pectin nanofibers were found to be antibacterial and biocompatible. These results demonstrate that MOF-contained pectin nanofibers are promising for biomedical applications.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Zirak Hassan Kiadeh S,Ghaee A,Farokhi M,Nourmohammadi J,Bahi A,Ko FKdoi
10.1016/j.ijbiomac.2021.01.058subject
Has Abstractpub_date
2021-01-12 00:00:00pages
351-365eissn
0141-8130issn
1879-0003pii
S0141-8130(21)00087-8journal_volume
173pub_type
杂志文章abstract::Herein, the immobilization of α-amylase onto hydroxyapatite (HA) and hydroxyapatite-decorated ZrO2 (10%wt) (HA-ZrO2) nanocomposite were investigated. The immobilization yield was 69.7% and 84% respectively. The structural differences were characterized using X-Ray diffraction, attenuated total reflectance-Fourier tran...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.11.150
更新日期:2021-01-15 00:00:00
abstract::Three polysaccharide fractions (TPS1, TPS2 and TPS3) with different molecular weights were obtained using ultra filtration membranes from crude tea polysaccharide (CTPS) extracted from abandoned lower grade tea leaves. Each fraction contained different contents of neutral sugar, uronic acid, protein, and total polyphe...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2011.12.028
更新日期:2012-04-01 00:00:00
abstract::Salt hydrate phase change materials (PCMs) possess the challenge of supercooling, which must be addressed to allow more efficient energy storage and utilisation. In this work, cellulose nanofibril (CNF), a versatile biopolymer was used to support and disperse silver nanoparticles (AgNPs), and the synthesised CNF/AgNPs...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2021.01.183
更新日期:2021-01-30 00:00:00
abstract::Chitosan (CS) is a well-known biological macromolecule having numerous applications due to its exceptional properties especially in the form of nanofibers. The antibacterial activity is compromised when co-polymers are added to electrospun CS but, the reproducibility can be enhanced which is key to commercialization. ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.06.022
更新日期:2019-08-15 00:00:00
abstract::A Cordyceps sinensis exopolysaccharide (EPS)-conjugated selenium nanoparticles (SeNPs) were successfully constructed through the reduction of SeO32-. The EPS-SeNPs were characterized in terms of formation, morphology, size, Se distribution and phase by UV-vis, FT-IR, transmission electron microscopy (TEM), dynamic lig...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.03.016
更新日期:2017-06-01 00:00:00
abstract::Intelligent packaging can provide better preservation and advanced convenience for consumers. In this study, corn starch and polyvinyl alcohol (PVA) were used to produce films. Two easily accessible anthocyanin sources-purple sweet potato extracts (PSPE) and red cabbage extracts (RCE), were added respectively to evalu...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.12.159
更新日期:2020-02-15 00:00:00
abstract::Bone is a highly integrative and dynamic tissue of the human body. It is continually remodeled by bone cells such as osteoblasts, osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular local...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章,评审
doi:10.1016/j.ijbiomac.2017.09.029
更新日期:2018-04-15 00:00:00
abstract::Galactomannan extracted from Trigonella persica endosperm like to other galactomannans is useful in the medicine and pharmaceutical industry such as drug delivery due to its unique physicochemical properties. As soon as germination takes place, the hydrolysis of galactomannan begins and its structure changes. Evaluati...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.06.225
更新日期:2019-09-15 00:00:00
abstract::The present study is aimed to evaluate the microwave-enforced sorption approach (MES) for instantaneous extraction and removal of trace concentration of metal ions using microwave-synthesized titanium oxide nanoparticles-bonded-chitosan nanolayer (NTiO2-NCh). The proposed and designed nanocomposite was characterized b...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2018.01.014
更新日期:2018-05-01 00:00:00
abstract::In recent years, aging has been reported to be regulated by HAT. In this study, the inhibitory effects of spermidine on the matrix metalloproteinase-2 (MMP-2) activity and expression were investigated in human dermal fibroblasts (HDFs). It was observed that spermidine inhibits MMP-2 activity and expression. In additio...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2012.08.013
更新日期:2012-12-01 00:00:00
abstract::An algal extracellular biopolymer (over 8.5 × 10(5)Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose a...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2011.08.029
更新日期:2011-12-01 00:00:00
abstract::The development of advanced nano-mediated biological macromolecular (PEGylated Chitosan) hydrogel materials is a vital approach to enhance the efficiency of cardiac tissue applications for treatment of cardiac tissue repair. Definite properties of PEG and chitosan hydrogel matrixes including swelling, mechanical stabi...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2018.04.196
更新日期:2018-10-01 00:00:00
abstract::Bacterially synthesized poly(hydroxyalkanoate)s (PHAs) suffers from low crystallization rate which is enhanced by using tailor-made oxalamide compounds as nucleators. The influence of nucleator configurations on the crystallization behaviour of the PHAs was investigated using differential scanning calorimetry (DSC), p...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.06.001
更新日期:2017-11-01 00:00:00
abstract::In this study, ginger polysaccharide (GP) was obtained from ginger by enzymatic method, its chemical properties and antitumor activity were investigated. The results indicated that the composition and proportion of GP were l‑rhamnose, d‑arabinose, d‑mannose, d‑glucose and d‑galactose in a molar ratio of 3.64:5.37:3.04...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2018.10.169
更新日期:2019-02-15 00:00:00
abstract::We describe the formation and properties of nanoconstruction that consists of the double-stranded DNA molecules located at distance of 35-50 A in the spatial structure of particles of their cholesteric liquid-crystalline dispersions and cross-linked by artificial nanobridges. The resulting nanostructures possess the p...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2005.04.004
更新日期:2005-07-01 00:00:00
abstract::It has been established that the equilibrium between duplex and G-quadruplex of the nuclease hypersensitivity element III1 (NHE III1) in human c-myc promoter is linked with this gene's transcription. Using NMR and ESI-MS, we have found a pyrene derivative, DMAPP, is able to modulate this equilibrium and, thus, might h...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2011.05.024
更新日期:2011-12-01 00:00:00
abstract::The aim of this study was to optimize the culture conditions for production, recovery and characterization of polyhydroxyalkanoate (PHA) from potential Bacillus cereus strain BNPI-92. Cost effective carbon sources such as crude oil (CO), rice bran (RB), sugar cane molasses (SCM) and wheat bran (WB) were evaluated for ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.11.138
更新日期:2020-08-01 00:00:00
abstract::Recombinant hybrid Manganese superoxide dismutase from Staphyloccus saphropyticus/S. equorum (rMnSODSeq) exhibits stability at high temperatures. The enzyme occurs as a dimer that dissociates around 52°C prior to unfolding of the monomer around 64°C, demonstrating contribution of the dimeric form to stability. Here, s...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.01.096
更新日期:2017-05-01 00:00:00
abstract::The goal of this work is to tune the formation and stability of the alginate-chitosan (AC) polyelectrolyte complexes (PECs) and microcapsules. Particularly, we explore the role of the conformation of chitosan on its interaction with alginate to understand the mechanism underpinning their interactions at the molecular ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2016.06.034
更新日期:2016-10-01 00:00:00
abstract::Brasenia schreberi (B. schreberi) is a rare and precious vegetable, which coat with a gelatinous mucilage. This study is aiming to investigate the relationship between structural characteristics and hypoglycemic activities of polysaccharides with different molecular weight (Mw) range. Three polysaccharides fractions, ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.05.129
更新日期:2019-08-15 00:00:00
abstract::The aim of this study was to develop a novel approach allowing simultaneous enrichment as well as specific and fast detection of Escherichia coli O157:H7 by indirect ELISA using optimized support membrane based on chitosan (CHI), cellulose nanocrystals (CNCs), and glycerol (GLY). Therefore, combining the step of the c...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.09.225
更新日期:2020-03-01 00:00:00
abstract::Many polysaccharides have biological activities and have been investigated for their antitumor effects. In this study, we investigated the anti-tumor activity and anti-virus activity of SNP-the water-soluble polysaccharides extracted from Sipunculus nudus on Hepg2.2.15. Flow cytometry analysis demonstrated that SNP in...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2016.03.022
更新日期:2016-06-01 00:00:00
abstract::The present study reports the re-examination of the crystal structure of mannan I by the X-ray powder diffraction study combined with the miniature crystal model simulation. A primary objective of this study was to investigate an adequate chain staggering position along the fiber axis. Among the several crystal struct...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/s0141-8130(97)00069-x
更新日期:1997-10-01 00:00:00
abstract::Polygonum multiflorum is a popular Chinese herbal medicine with various pharmacological functions. In this study, the ultrasonic-assisted extraction condition, structural characterization and antitumor activity of a polysaccharide from roots of P. multiflorum were investigated. The ultrasonic-assisted extraction condi...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2016.05.061
更新日期:2016-10-01 00:00:00
abstract::This study is focusing to develop a porous biocompatible scaffold using hydroxyethyl cellulose (HEC) and poly (vinyl alcohol) (PVA) with improved cellular adhesion profiles and stability. The combination of HEC and PVA were synthesized using freeze-drying technique and characterized using SEM, ATR-FTIR, TGA, DSC, and ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2018.10.156
更新日期:2019-02-01 00:00:00
abstract::The objective of present investigation was to optimize the interaction between carboxymethylated psyllium arabinoxylan and chitosan to prepare polyelectrolyte naoparticles for drug delivery applications. Arabinoxylan extracted from psyllium was carboxymethylated by reacting with monochloroacetic acid under alkaline co...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2014.08.051
更新日期:2015-01-01 00:00:00
abstract::The emergence of the global pandemic caused by the novel SARS-CoV-2 virus has motivated scientists to find a definitive treatment or a vaccine against it in the shortest possible time. Current efforts towards this goal remain fruitless without a full understanding of the behavior of the virus and its adaptor proteins....
journal_title:International journal of biological macromolecules
pub_type: 杂志文章,评审
doi:10.1016/j.ijbiomac.2020.09.204
更新日期:2020-12-15 00:00:00
abstract::The conventional vulcanization process applied to elastomers is irreversible and hinders therefore their useful recycling. We demonstrate here that natural rubber can be reversibly crosslinked via the Diels-Alder coupling of furan and maleimide moieties. The furan-modified natural rubber used in this strategy was also...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2016.11.102
更新日期:2017-02-01 00:00:00
abstract::Immunoscreening of a cDNA expression library of the Rhipicephalus (Boophilus) annulatus tick with purified rabbit anti-R annulatus salivary glands antigens polyclonal antibodies led to the identification of a 661bp sequence. The sequence includes an open reading frame of 543bp encoding a protein of 180 amino acids wit...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2010.08.006
更新日期:2010-12-01 00:00:00
abstract::Green biocomposites based on corn starch plasticized with isosorbide and glycerol and filled with microcrystalline cellulose (MCC) were processed. The structural interactions, dynamomechanical properties, water absorption, and soil biodegradability were investigated by different techniques considering the effect of th...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.08.075
更新日期:2020-12-01 00:00:00