当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Glycation of hemoglobin leads to the immunogenicity as a result of neo-epitope generation.

Glycation of hemoglobin leads to the immunogenicity as a result of neo-epitope generation.

Abstract：

:Non-enzymatic glycation occurs rapidly which ultimately leads to the formation of advanced glycation endproducts (AGEs). These AGEs have shown to associated with the development of many diseases such as diabetes-mellitus. This study is focused on immunological characterization of glycated-Hb induced by d-ribose. Here, we analysed the immunogenicity of glycated-Hb by direct binding and competitive inhibition ELISA. Direct binding ELISA confirmed that glycated-Hb was highly immunogenic and induced high titre antibodies as compared to native-Hb. The antigen binding specificity and cross reactivity of these antibodies were also screened by competitive inhibition ELISA. The IgG from rabbit sera showed enhanced binding of glycated-Hb than native-Hb. Thus, it is possible that alterations in Hb induced by d-ribose could have generated highly immunogenic neoepitopes. Moreover, induced antibodies were also found to cross-react with other modified/native proteins. On the basis of the results of this study, we presume that this type of structural perturbations in Hb in vivo by d-ribose might take place in untreated diabetic condition that could induce such type of immunogenic auto-antibodies. Furthermore, increased level of these auto-antibodies could serve as a biomarker in diabetes and its progression.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Siddiqui Z,Faisal M,Alatar AA,Ahmad S

doi

10.1016/j.ijbiomac.2018.11.063

subject

Has Abstract

pub_date

2019-02-15 00:00:00

pages

427-435

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)34545-8

journal_volume

123

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Down-regulated miR-187 promotes oxidative stress-induced retinal cell apoptosis through P2X7 receptor.

    abstract：:Several microRNAs (miRNAs) expressed in the retina were confirmed to involve in retinal cell apoptosis, which was closely linked with the development of retinal diseases. Our previous studies have confirmed a vital role of miR-187 in retinal cells apoptosis. The aim of this study was to further elucidate the precise r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.166

    authors： Zhang QL,Wang W,Alatantuya,Dongmei,Lu ZJ,Li LL,Zhang TZ

    更新日期：2018-12-01 00:00:00

  • A new water-soluble polysaccharide from Echinops pungens Trautv roots. Part I. Isolation, purification, characterization and antioxidant activity.

    abstract：:EPPS, a new heteropolysaccharide from Echinops pungens roots, was extracted by warm water (70 °C) and fortuitously purified using column chromatographies on DEAE-cellulose A52 and Sephadex G-100. Total carbohydrate content, specific optical rotation and molecular mass of EPPS were 98.3%, -88.2 and 65.7 kDa, respective...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.128

    authors： Hoseiniyan Benvidi SM,Jahanbin K

    更新日期：2020-10-15 00:00:00

  • Hydroxypropylation of cross-linked sesbania gum, characterization and properties.

    abstract：:Sesbania gum (SG) was successfully modified by combining cross-linking with hydroxypropylation in solvent of ethanol. The hydroxypropylation technology parameters were optimized by the orthogonal test. The results indicated that both cross-linking and hydroxypropylation could improve the freeze-thaw stability, acid an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.188

    authors： Tang H,Liu Y,Li Y,Li Q,Liu X

    更新日期：2020-06-01 00:00:00

  • Characterization of polysaccharides isolated from Hericium erinaceus and their protective effects on the DON-induced oxidative stress.

    abstract：:In this study, the structure characteristic of the Hericium erinaceus polysaccharide (HEP) was investigated using Fourier transformed infrared spectrometry (FT-IR), gas chromatography-mass spectrometry (GC-MS), gel permeation chromatography (GPC), methylation and nuclear magnetic resonance (NMR). The results showed th...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.223

    authors： Qin T,Liu X,Luo Y,Yu R,Chen S,Zhang J,Xu Y,Meng Z,Huang Y,Ren Z

    更新日期：2020-06-01 00:00:00

  • Bacterial cellulose in biomedical applications: A review.

    abstract：:Bacterial cellulose (BC) derived materials represents major advances to the current regenerative and diagnostic medicine. BC is a highly pure, biocompatible and versatile material that can be utilized in several applications - individually or in the combination with different components (e.g. biopolymers and nanoparti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2017.05.171

    authors： Picheth GF,Pirich CL,Sierakowski MR,Woehl MA,Sakakibara CN,de Souza CF,Martin AA,da Silva R,de Freitas RA

    更新日期：2017-11-01 00:00:00

  • Box-Behnken design to optimize the synthesis of new crosslinked chitosan-glyoxal/TiO2 nanocomposite: Methyl orange adsorption and mechanism studies.

    abstract：:A crosslinked chitosan-glyoxal/TiO2 nanocomposite (CCG/TNC) was synthesized by loading different ratios of TiO2 nanoparticles into polymeric matrix of crosslinked chitosan-glyoxal (CCG) to be a promising biosorbent for methyl orange (MO). Box-Behnken design (BBD) in response surface methodology (RSM) was applied to op...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.025

    authors： Mohammad AT,Abdulhameed AS,Jawad AH

    更新日期：2019-05-15 00:00:00

  • Preparation of Ag-cellulose nanocomposite for the selective detection and quantification of mercury at nanomolar level and the evaluation of its photocatalytic performance.

    abstract：:Mercury is a toxic heavy metal that reaches to the water bodies mainly by coal burning, mining and petrol refining. The study was focused to investigate the application of Ag-cellulose nanocomposite to detect and quantify mercury colorimetrically. The Ag-cellulose nanocomposite was characterized by X-ray diffraction, ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.119

    authors： Balasurya S,Syed A,Thomas AM,Bahkali AH,Al-Rashed S,Elgorban AM,Raju LL,Das A,Khan SS

    更新日期：2020-12-01 00:00:00

  • Role of peroxynitrite induced structural changes on H2B histone by physicochemical method.

    abstract：:Histones are small highly conserved cationic proteins which bind DNA and remain confined in the nucleus. These histones are quite vulnerable to oxidizing and nitrating agents. Peroxynitrite is a powerful oxidant and nitrating agent present in the biological system. In this study, peroxynitrite-induced nitration and ox...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.10.085

    authors： Khan MA,Alam K,Dixit K,Rizvi MM

    更新日期：2016-01-01 00:00:00

  • In vitro and in vivo antioxidant activity of a fructan from the roots of Arctium lappa L.

    abstract：:To explore new antioxidant resource from food, a water-soluble polysaccharide (ALP1) was extracted and purified from the roots of Arctium lappa L. (A. lappa L.) through hot water extraction followed by ethanol precipitation, ion-exchange chromatography and gel filtration. The antioxidant activity of ALP1 was then eval...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.01.062

    authors： Liu W,Wang J,Zhang Z,Xu J,Xie Z,Slavin M,Gao X

    更新日期：2014-04-01 00:00:00

  • Electrospinning of multifunctional cellulose acetate membrane and its adsorption properties for ionic dyes.

    abstract：:Electrospinning of cellulose acetate with appropriated solvent system is the most straightforward method for fabricating micro- and nanofibers. To simultaneously and effectively remove both cationic and anionic dyes, a novel cost-effective multifunctional cellulose acetate (CA) fibers membrane was prepared by electros...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.249

    authors： Chen W,Ma H,Xing B

    更新日期：2020-05-03 00:00:00

  • Elastic and biodegradable chitosan/agarose film revealing slightly acidic pH for potential applications in regenerative medicine as artificial skin graft.

    abstract：:The aim of this work was to develop new method for the production of chitosan/agarose (CHN/A) film that could serve as a potential artificial skin substitute for regenerative medicine applications. Within this new production method, the concentrations of biomaterial components (chitosan in CH3COOH and agarose in NaOH)...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.099

    authors： Vivcharenko V,Benko A,Palka K,Wojcik M,Przekora A

    更新日期：2020-12-01 00:00:00

  • Sustained release gastroretentive tablet of metformin hydrochloride based on poly (acrylic acid)-grafted-gellan.

    abstract：:Development of a gastroretentive sustained release tablet of metformin based on poly (acrylic acid)-grafted-gellan (PAAc-g-GG) is the main purpose of this study. At first, PAAc-g-GG was synthesized by microwave-promoted free radical initiation method using cerric (IV) ammonium nitrate (CAN) as redox initiator and char...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.12.022

    authors： Sarkar D,Nandi G,Changder A,Hudati P,Sarkar S,Ghosh LK

    更新日期：2017-03-01 00:00:00

  • Isolation and characterization of lignocellulose nanofibers from different wheat straw pulps.

    abstract：:Wheat straw was cooked under different pulping processes: Soda (100°C, 7% NaOH, 150min), Kraft (170°C, 16% alkalinity, 25% sulfidity, 40min) and Organosolv (210°C, 60% ethanol, 60min). Once the pulps were obtained, lignocellulose nanofibers (LCNF) were isolated by mechanical process and TEMPO-mediated oxidation follow...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.08.019

    authors： Sánchez R,Espinosa E,Domínguez-Robles J,Loaiza JM,Rodríguez A

    更新日期：2016-11-01 00:00:00

  • Role of Au(III) coordination by polymer in "green" synthesis of gold nanoparticles using chitosan derivatives.

    abstract：:Here we report "green" synthesis of gold nanoparticles in solutions of heterocyclic chitosan derivatives (N-(4-imidazolyl)methylchitosan (IMC), N-2-(2-pyridyl)ethylchitosan (2-PEC), and N-2-(4-pyridyl)ethylchitosan (4-PEC)) and show how efficiency of Au(III) binding to polymer influences the Au(III) reduction rate and...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.05.102

    authors： Pestov A,Nazirov A,Privar Y,Modin E,Bratskaya S

    更新日期：2016-10-01 00:00:00

  • Effects of organic solvents on the activity of free and immobilised laccase from Rhus vernicifera.

    abstract：:Rhus laccase (RL) was covalently immobilised onto chitosan, and the effects of immobilisation on pH optimum, enzyme activity, thermostability, and re-use evaluated, using either N,N-dimethyl-p-phenylenediamine or 2,6-dimethoxyphenol as substrate. Immobilisation greatly enhanced enzyme thermostability, resulted in negl...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.07.003

    authors： Wan YY,Lu R,Xiao L,Du YM,Miyakoshi T,Chen CL,Knill CJ,Kennedy JF

    更新日期：2010-11-01 00:00:00

  • Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota.

    abstract：:The present study aimed to evaluate the antidepressant-like effect of a polysaccharide (OP), which is isolated from okra (Abelmoschus esculentus (L) Moench), in CUMS-induced mice and its possible mechanisms. OPT, FST and TST were employed to examine the anxiety and depressive behavior in CUMS-induced mice and fecal mi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.138

    authors： Yan T,Nian T,Liao Z,Xiao F,Wu B,Bi K,He B,Jia Y

    更新日期：2020-02-01 00:00:00

  • Structure-activity relationship of a recombinant hybrid Manganese superoxide dismutase of Staphylococcus saprophyticus/S. equorum.

    abstract：:Recombinant hybrid Manganese superoxide dismutase from Staphyloccus saphropyticus/S. equorum (rMnSODSeq) exhibits stability at high temperatures. The enzyme occurs as a dimer that dissociates around 52°C prior to unfolding of the monomer around 64°C, demonstrating contribution of the dimeric form to stability. Here, s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.01.096

    authors： Retnoningrum DS,Arumsari S,Artarini A,Ismaya WT

    更新日期：2017-05-01 00:00:00

  • On the temperature-induced coil to globule transition of poly-N-isopropylacrylamide in dilute aqueous solutions.

    abstract：:Poly-N-isopropylacrylamide (PNIPAM) is a chemical isomer of poly-leucine, having the polar peptide group in the side-chain rather than in the backbone. It has been demonstrated experimentally that PNIPAM dissolved in aqueous solution undergoes a collapse transition from coil to globule on increasing temperature above ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(99)00122-1

    authors： Graziano G

    更新日期：2000-03-16 00:00:00

  • Preparation screening, production optimization and characterization of exopolysaccharides produced by Lactobacillus sanfranciscensis Ls-1001 isolated from Chinese traditional sourdough.

    abstract：:The present study focused on preparation screening, production optimization and characterization of exopolysaccharides (EPS) produced by Lactobacillus sanfranciscensis isolated from a Chinese traditional sourdough sample. In addition, in vitro antioxidant activity of pure EPS was determined. A total of 51 strains of L...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.077

    authors： Zhang G,Zhang W,Sun L,Sadiq FA,Yang Y,Gao J,Sang Y

    更新日期：2019-10-15 00:00:00

  • Botryosphaeran, a (1 → 3)(1 → 6)-β-D-glucan, reduces tumor development and cachexia syndrome in obese male rats by increasing insulin sensitivity and FOXO3a activity.

    abstract：:Obesity is an important risk factor in tumor development. Botryosphaeran, a (1 → 3)(1 → 6)-β-D-glucan, produced by the fungus Botryosphaeria rhodina (MAMB-05), is a high molecular mass, water-soluble exopolysaccharide. It consists of a main chain of (1 → 3)-linked β-d-glucose units, with a degree of branching of ~22% ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.168

    authors： Geraldelli D,Ribeiro MC,Medeiros TC,Comiran PK,Martins KO,Oliveira MF,Oliveira GA,Dekker RFH,Barbosa-Dekker AM,Alegranci P,Queiroz EAIF

    更新日期：2020-12-15 00:00:00

  • In vitro digestion and human gut microbiota fermentation of longan pulp polysaccharides as affected by Lactobacillus fermentum fermentation.

    abstract：:This study investigated the effect of Lactobacillus fermentum fermentation treatment on the gastrointestinal digestion and fermentation in vitro of polysaccharides from longan pulp. Polysaccharide isolated from unfermented and fermented longan pulp named LP and LP-F, respectively. The molecular weight of LP-F declined...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.059

    authors： Huang F,Hong R,Yi Y,Bai Y,Dong L,Jia X,Zhang R,Wang G,Zhang M,Wu J

    更新日期：2020-03-15 00:00:00

  • In vivo antioxidant and anti-inflammatory effects of soluble dietary fiber Konjac glucomannan in type-2 diabetic rats.

    abstract：:Although the anti-diabetic properties of Konjac glucomannan (KGM) have been reported previously; however, the molecular pathways of its anti-diabetic properties are not clear. The present study hypothesized that KGM could mitigate oxidative stress and inflammation. Three doses of KGM (40, 80, 120 mg/kg b.w.) decreased...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.105

    authors： Zhao Y,Jayachandran M,Xu B

    更新日期：2020-09-15 00:00:00

  • Factors affecting the association of single- and double-stranded RNAs with montmorillonite nanoclays.

    abstract：:Montmorillonite (MMT) nanoclays exist as single and stacked sheet-like structures with large surface areas that can form stable associations with many naturally occurring biomolecules, including nucleic acids. They have been utilized successfully as vehicles for delivery of both drugs and genes into cells. Most previo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.12.124

    authors： Gujjari A,Rodriguez BV,Pescador J,Maeder C,Beall GW,Lewis LK

    更新日期：2018-04-01 00:00:00

  • Polymer coated mesoporous ceramic for drug delivery in bone tissue engineering.

    abstract：:Treatment strategy for various bone fracture and defects the researchers are focusing to develop a new carrier for delivering the drug into injured area with controlled and sustained manner using biomaterials with dynamic architecture orientation. Ceramic materials are resembled with bone compositional architecture an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2017.11.146

    authors： Subhapradha N,Abudhahir M,Aathira A,Srinivasan N,Moorthi A

    更新日期：2018-04-15 00:00:00

  • In-situ lignin drives lytic polysaccharide monooxygenases to enhance enzymatic saccharification.

    abstract：:Recently low-molecular lignin was reported to activate lytic polysaccharide monooxygenases (LPMOs) to oxidize cellulose. However, whether lignin formed in cell wall can play the role as electron donor for LPMOs is still largely unknown due to the complex ultrastructure of lignocellulosic biomass. In this study, we pre...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.014

    authors： Ni H,Li M,Li F,Wang L,Xie S,Zhang X,Yu H

    更新日期：2020-10-15 00:00:00

  • Use of guar gum, gum arabic, pectin, beta-glucan and inulin for microencapsulation of anthocyanins from chokeberry.

    abstract：:The aim of this study was to use micro-encapsulation technology to create microcapsules containing anthocyanins from chokeberry with guar gum, gum arabic, pectin, β-glucan and inulin as wall material. Aqueous extracts from chokeberry fruit were enclosed and spray dried using maltodextrin as a coating material with the...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.073

    authors： Pieczykolan E,Kurek MA

    更新日期：2019-05-15 00:00:00

  • Antiplatelet and antithrombotic activity of a fibrin(ogen)olytic protease from Bacillus cereus strain FF01.

    abstract：:Fibrin(ogen)olytic enzymes offer great promise for the treatment of thrombosis associated disorders. The present study describes the characterization of an extracellular fibrin(ogen)olytic serine protease (named Bacethrombase) purified from the Bacillus cereus strain FF01. The molecular mass of the Bacethrombase was d...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.04.075

    authors： Majumdar S,Dutta S,Das T,Chattopadhyay P,Mukherjee AK

    更新日期：2015-08-01 00:00:00

  • Prilling and characterization of hydrogels and derived porous spheres from chitosan solutions with various organic acids.

    abstract：:This work emphazises the importance of the solubilizing conditions for the elaboration of chitosan hydrogel beads, which were produced using electromagnetic laminar jet breakup technology, resulting in dried porous beads by further freeze-drying. Paramaters such as the acid nature and concentration (acetic, formic, ci...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.01.216

    authors： Lakehal I,Montembault A,David L,Perrier A,Vibert R,Duclaux L,Reinert L

    更新日期：2019-05-15 00:00:00

  • Facile synthesis of a high efficiency and durability L-citrulline flame retardant for cotton.

    abstract：:A novel flame retardant (FR), the ammonium salt of citrulline-penta (methylphosphonic acid) (ACPMPA) based on L-citrulline was synthesized, and its structure was characterized by 13C, 1H, and 31P nuclear magnetic resonance (NMR) spectroscopy. The ACPMPA flame retardant molecule contains five ammonium salts of phosphor...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.022

    authors： Chen Y,Liu S,Wan C,Zhang G

    更新日期：2021-01-01 00:00:00

  • Characterization of a novel bifunctional mannuronan C-5 epimerase and alginate lyase from Pseudomonas mendocina. sp. DICP-70.

    abstract：:Alginate is a family of industrially important linear polymers consisting of β-D-mannuronic acid (M) and its C-5 epimer α-L-guluronic acid (G). The function of alginate is closely related to the ratio of M/G. Mannuronan C-5 epimerase, which converts M to G, is a key enzyme involved in the biosynthesis of alginate. A n...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.126

    authors： Sun M,Sun C,Li T,Li K,Yan S,Yin H

    更新日期：2020-05-01 00:00:00