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Characterization of polysaccharides isolated from Hericium erinaceus and their protective effects on the DON-induced oxidative stress.

Abstract：

:In this study, the structure characteristic of the Hericium erinaceus polysaccharide (HEP) was investigated using Fourier transformed infrared spectrometry (FT-IR), gas chromatography-mass spectrometry (GC-MS), gel permeation chromatography (GPC), methylation and nuclear magnetic resonance (NMR). The results showed that HEP, with a molecular weight of 43 KDa, was mainly composed of glucose and rhamnose. The linkages of the sugar residues of HEP were → 6) β-d-Glcp-(1 → and → 2) -α-l-Rhap-(1 → residue at the end of the branches. The Fusarium toxin deoxynivalenol (DON)-induced cellular injury model for IPEC-J2 cells was established and used to investigate the protective effects of HEP against the oxidative stress. The results suggest that HEP could significantly protect IPEC-J2 cells from DON-induced oxidative stress, inhibit DON-induced apoptosis and reduce the production of reactive oxygen species (ROS). Overall, this study suggested that HEP could be explored as potential antioxidant agents for DON-induced intestinal mucosa injury.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Qin T,Liu X,Luo Y,Yu R,Chen S,Zhang J,Xu Y,Meng Z,Huang Y,Ren Z

doi

10.1016/j.ijbiomac.2019.10.223

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

1265-1273

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)37739-6

journal_volume

152

pub_type

杂志文章

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