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A cutting-edge immunoinformatics approach for design of multi-epitope oral vaccine against dreadful human malaria.

Abstract：

:Human malaria is a pathogenic disease mainly caused by Plasmodium falciparum, which was responsible for about 405,000 deaths globally in the year 2018. To date, several vaccine candidates have been evaluated for prevention, which failed to produce optimal output at various preclinical/clinical stages. This study is based on designing of polypeptide vaccines (PVs) against human malaria that cover almost all stages of life-cycle of Plasmodium and for the same 5 genome derived predicted antigenic proteins (GDPAP) have been used. For the development of a multi-immune inducer, 15 PVs were initially designed using T-cell epitope ensemble, which covered >99% human population as well as linear B-cell epitopes with or without adjuvants. The immune simulation of PVs showed higher levels of T-cell and B-cell activities compared to positive and negative vaccine controls. Furthermore, in silico cloning of PVs and codon optimization followed by enhanced expression within Lactococcus lactis host system was also explored. Although, the study has sound theoretical and in silico findings, the in vitro/in vivo evaluation seems imperative to warrant the immunogenicity and safety of PVs towards management of P. falciparum infection in the future.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Pritam M,Singh G,Swaroop S,Singh AK,Pandey B,Singh SP

doi

10.1016/j.ijbiomac.2020.04.191

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

159-179

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)33050-6

journal_volume

158

pub_type

杂志文章

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