当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Heme degradation and iron release of hemoglobin and oxidative stress of lymphocyte cells in the presence of silica nanoparticles.

Heme degradation and iron release of hemoglobin and oxidative stress of lymphocyte cells in the presence of silica nanoparticles.

Abstract：

:Silica nanoparticles (SiO2 NPs) have been widely used in the medical and food sciences. However, their toxic effects against bio-macromolecules and cells are not well understood. The present study was aimed to investigate the adverse effects of fabricated SiO2 NPs on the human hemoglobin (Hb) by FTIR, CD, fluorescence, and UV-vis spectroscopic techniques. Moreover, the toxic effects of SiO2 NPs on the human lymphocyte cell was assessed by trypan blue, reactivate oxygen species (ROS), and apoptosis assays. It was shown that synthesized SiO2 NPs have an amorphous structure with dominant size of around 20-30 nm. FTIR results showed that SiO2 NPs bind to Hb and induce significant structural changes on the native structure of Hb. Near CD spectroscopy depicted that SiO2 NPs induced tertiary structural changes and heme displacement. Fluorescence spectroscopy demonstrated the production of heme degradation species in the Hb solution after interaction with SiO2 NPs. UV-vis spectroscopy experiment indicated the release of iron form Hb after interaction with SiO2 NPs in a concentration dependent manner. Live-dead staining, ROS detection and flow cytometry analysis revealed that human lymphocyte was sensitive towards the toxicity of SiO2 NPs in a ROS-mediated apoptosis mechanism. In conclusion, SiO2 NPs exhibited concentration-dependent toxicity.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Azimipour S,Ghaedi S,Mehrabi Z,Ghasemzadeh SA,Heshmati M,Barikrow N,Attar F,Falahati M

doi

10.1016/j.ijbiomac.2018.06.128

subject

Has Abstract

pub_date

2018-10-15 00:00:00

pages

800-807

issue

Pt A

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)31050-X

journal_volume

118

pub_type

杂志文章

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