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Tough chitosan hydrogel based on purified regeneration and alkaline solvent as biomaterials for tissue engineering applications.

Abstract：

:The chitosan based on purified regeneration could be dissolved in 6wt% aqueous NaOH without freeze-thawing cycles and acetylation processing, and such a solution system was effective and different from other dissolving methods Upon heating, a tough hydrogel was constructed from the chitosan (purified regeneration) alkaline solution. The results of XRD, TEM, SEM and rheology analysis proved that chitosan easily aggregated in the solution and formed a nanofibers network to gelate at elevated temperature and concentration. The merely chitosan hydrogel had a uniform network structure and its (5wt%) compressive fracture stress could reach 0.2MPa. Furthermore, the hydrogels exhibited excellent biodegradability, blood compatibility and cellular compatibility. Therefore, the tough chitosan hydrogels may have a wide range of applications in biomedicine.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Bi S,Bao Z,Bai X,Hu S,Cheng X,Chen X

doi

10.1016/j.ijbiomac.2017.06.017

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

224-231

issue

Pt A

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)32764-7

journal_volume

104

pub_type

杂志文章

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