当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Hepatoprotective effect of a polysaccharide from Crassostrea gigas on acute and chronic models of liver injury.

Hepatoprotective effect of a polysaccharide from Crassostrea gigas on acute and chronic models of liver injury.

Abstract：

:A water-soluble polysaccharide was isolated from Crassostrea gigas (CGPS-1) by hot-water extraction, isoelectric precipitation, hydrolysis and ultrafiltration without using ethanol. Based on the calibration with Dextran, CGPS-1 had a molecular weight of approximately 6.5×10(6) Da. CGPS-1 was analyzed using high-performance liquid chromatography, Fourier-transform infrared spectroscopy and (1)H and (13)C nuclear magnetic resonance spectroscopy. Based on the data, CGPS-1 was found to be a uniform glucose polymer. The protective effect of CGPS-1 on acute carbon tetrachloride- and chronic ethanol-induced liver injury was investigated in mice. Treatment with CGPS-1 decreased serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), and malondialdehyde (MDA) levels; increased superoxide dismutase (SOD) activity; and improved hepatic injury in both the acute and chronic models of liver injury in mice. These results suggest that CGPS-1 possesses potent hepatoprotective activity.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Shi X,Ma H,Tong C,Qu M,Jin Q,Li W

doi

10.1016/j.ijbiomac.2015.03.056

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

142-8

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)00208-1

journal_volume

78

pub_type

杂志文章

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