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Structural features and in vivo antitussive activity of the water extracted polymer from Glycyrrhiza glabra.

Abstract：

:Antitussive drugs are amongst the most widely used medications worldwide; however no new class of drugs has been introduced into the market for many years. Herein, we have analyzed the water-extracted polymeric fraction (WE) of Glycyrrhiza glabra. This arabinogalactan protein enriched fraction, ≥ 85% of which gets precipitated with Yariv reagent, consisted mainly of 3- and 3,6-linked galactopyranosyl, and 5- and 3,5-linked arabinofuranosyl residues. Peroral administration of this polymer in a dose of 50mg/kg body weight decreases the number of citric acid induced cough efforts in guinea pigs more effectively than codeine. It does not induce significant change in the values of specific airway resistance or provoked any observable adverse effects.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Saha S,Nosál'ová G,Ghosh D,Flešková D,Capek P,Ray B

doi

10.1016/j.ijbiomac.2011.02.003

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

634-8

issue

4

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(11)00056-0

journal_volume

48

pub_type

杂志文章

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