Abstract:
:Hydrogels based on pectin and cellulose nanocrystals (CNC) were used in our study to nucleation and growth of hydroxyapatite (HAp) by the biomimetic method. In this study, we evaluated the direct impact of the different percentages of CNC on pectin hydrogel and the influence of HAp obtained through two methods. CNC were obtained from HCl hydrolysis following chemical functionalization through vinyl groups. The percentage of CNC positively induces thermal stability, mechanical properties and HAp mineralization from biomimetic using simulated body fluid (1.5 SBF). Hydrogels with 5% of CNC showed a higher amount of HAp immersed for 14 days, about 28% of HAp. The obtained hydrogels were compared with hydrogels containing 20% of HAp nanoparticles obtained by chemical precipitation. Biocompatibility of the hydrogels was evaluated by cell viability using fibroblasts (L929). In general, the hydrogels obtained through the biomimetic method show slightly larger biocompatibility compared to the hybrid hydrogels obtained from chemical precipitation.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Catori DM,Fragal EH,Messias I,Garcia FP,Nakamura CV,Rubira AFdoi
10.1016/j.ijbiomac.2020.12.012subject
Has Abstractpub_date
2021-01-15 00:00:00pages
726-735eissn
0141-8130issn
1879-0003pii
S0141-8130(20)35170-9journal_volume
167pub_type
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